Can You Take Gaba And CBD Oil Together

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CBD has a lot to offer, but why stop there? Where CBD falls short, other supplements can pick up the slack. Here are five other supplements to take with CBD. In this article, we will examine how GABA and CBD work together to create the perfect combination for tackling sleep-related issues

Five Supplements You Should Be Taking With Your CBD

CBD has a lot to offer, but why stop there? Where CBD falls short, other supplements can pick up the slack. Here’s five other supplements to take with CBD.

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Cannabidiol (CBD) is quickly becoming one of the most popular nutritional supplements on the market. It’s highly revered for its ability to regulate metabolic, immune, and neurological homeostasis — which is a fancy word meaning “balance.”

Negative health conditions can be attributed to an imbalance of one organ system or another. As a result, CBD is suggested to offer a wide range of health benefits throughout the body.

Although CBD has many uses, combining it with other synergistic nutritional and herbal supplements can optimize its effects.

In this article, we’re going to highlight why you should be combining your CBD with other supplements and which supplements you should consider for different symptoms.

Let’s get started by discussing exactly why you shouldn’t rely on just CBD to manage your symptoms.

Table of Contents

Why You Should Combine CBD with Other Supplements

The use of CBD as a form of medicine isn’t a new concept — people have been using it for centuries to treat everything from pain and inflammation to age-related cognitive decline.

However, people rarely use cannabis on its own to treat conditions.

In all forms of herbal medicine, plants are combined to enhance their effects based on the symptoms presented.

This is a common practice in herbal medicine, even in the modern world.

Only in the modern era have health practitioners chosen to take a more reductionist approach to medicine. Instead of combining multiple herbs or medicines to leverage their strengths and weaknesses, a single compound is prescribed.

Using a single compound (pharmaceutical) has advantages during the research stage because it’s easier to see what is responsible for a given result. Compounded medicines, on the other hand, are much harder to study because it’s challenging to identify exactly what effect each component is producing.

However, most people don’t care about knowing exactly which compound is producing the bulk of the effects — they just want to feel better.

By far the best way to leverage health supplements is through intelligent formulation. This works by taking 2 to 5 supplements that work well together to produce a more significant overall benefit.

For example, let’s say you’re taking CBD for joint pain — a popular application of the compound. Now, you could stop there and let the CBD do its job alone, but it’s going to have limitations.

CBD helps block pain and lower inflammation — both of which are common causes of the pain associated with the condition.

However, what happens if the cause of pain is a loss of cartilage tissue? CBD isn’t going to do much to support that process — so it’s better to combine it with something such as glucosamine, which is beneficial for repairing cartilage. Taken together, you can both speed the repair of your cartilage tissue in the joint and provide symptomatic support for the pain.

This is just one example of when it’s more beneficial to combine other supplements with CBD to achieve better results. Let’s go through five more examples.

Top Five Supplements to Take with Your CBD

Choosing which supplements to use alongside your CBD is going to depend on the symptoms you’re trying to address.

1. CBD & L-Theanine for Anxiety

There are many causes of anxiety, but the effects we feel during an anxiety attack are a direct result of overactivation of the nervous system — known as the fight-or-flight response.

CBD calms the nervous system through its ability to increase the activity of a neurotransmitter known as GABA — which acts as the brake pedal for the nervous system.

When our nervous system speeds up too fast, GABA slows it back down again.

Stepping on the brake pedal is great, but only if you ease off the gas pedal at the same time.

This is where L-theanine comes in.

L-theanine is an amino acid found in the tea plant (Camellia sinensis). Its structure closely resembles a neurotransmitter known as glutamate — which is essentially the gas pedal in the brain. It’s one of the primary stimulatory neurotransmitters in the brain.

The similarity in the chemical structure of L-theanine to glutamate allows it to bind to glutamate receptors — only it doesn’t produce any effects [10]. Instead, L-theanine blocks glutamate from hitting these receptors — effectively stepping off the gas pedal to allow CBD to calm us down.

2. CBD & Ashwagandha (KSM-66) for Stress

An effective stress response is critical for maintaining optimal health.

Stress comes in all forms, but all stress has a similar effect on the body. It activates a region deep within the body known as the hypothalamus. The hypothalamus then sends hormones to the adrenal glands, which initiate the production of a hormone known as cortisol.

Cortisol then:

  • Inhibits the immune system
  • Inhibits digestion
  • Increases heart rate
  • Increases blood pressure
  • Dilates the airways
  • Stimulates the brain
  • Forces the liver to dump glucose into the bloodstream

Cortisol is helpful in the short term for activating the stress response when it’s necessary — but if allowed to persist for too long, it can cause serious long-term problems, including insomnia, brain fog, lowered immunity, and weight gain, and even more serious complications such as diabetes and heart disease.

Ashwagandha supplementation has been shown to lower cortisol levels over time with regular use [1, 2]. There are several theories as to how it achieves this. The predominant idea is that it increases the conversion of cortisol to inactive metabolites by increasing the ability of the hypothalamus to regulate cortisol levels and handle stress.

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CBD pairs nicely with ashwagandha because it achieves similar results by acting on other areas of the nervous system, including GABA [3].

These compounds may work together to alleviate chronic stress from the top down.

3. CBD, Curcumin, & Boswellia for Chronic Inflammation

Inflammation is incredibly complex — entire textbooks are dedicated to the topic without even grazing the surface.

Inflammation can vary a lot depending on the cause of the inflammation, which means that the inflammation experienced during an autoimmune disorder is very different from the inflammation experienced when you injure yourself.

Long-term (chronic) inflammation is also very different from short-term (acute) inflammation.

CBD is excellent for addressing both chronic and acute inflammation because it blocks many of the molecules involved in triggering inflammation. However, it has its limits.

Adding curcumin (the active constituent in turmeric) and Boswellia (another name for frankincense) may further enhance the effects of CBD by offering additional anti-inflammatory benefits through different mechanisms.

Curcumin and Boswellia stop inflammation by blocking key enzymes involved with manufacturing inflammatory compounds known as COX and 5-LOX.

Curcumin blocks COX [6], while Boswellia is better for stopping the related enzyme 5-LOX [7].

Taking all three supplements together is going to offer the most profound benefits because all of these actions are important for stopping inflammation.

By blocking these enzymes on top of key inflammatory messengers by CBD, the inflammation process comes to a screeching halt.

4. CBD, Glucosamine, & Chondroitin Sulphate for Joint Pain

CBD is useful for alleviating joint pain involved with both rheumatoid arthritis and osteoarthritis because of its analgesic and anti-inflammatory benefits.

Inflammation is a key component of the underlying causes of arthritis, but it’s not the only cause.

One of the biggest problems leading to chronic joint pain as a result of arthritis is a gradual breakdown of cartilage in the joints. Cartilage is designed to protect the joints so that bone doesn’t rub directly against another bone. Instead, the cartilage and a slippery fluid called synovial fluid allow the joints to move freely without causing any damage to the bones.

As the cartilage disappears, the rubbing of bone on bone causes extreme pain and worsens inflammation — ultimately leading to even faster degeneration of the cartilage and a buildup of scar tissue.

CBD is effective for reducing symptomatic pain in the joints and fighting inflammation — but it does very little for restoring lost bone cartilage.

This is where glucosamine and chondroitin sulfate comes in.

Both of these supplements are known for their ability to provide essential precursors for the body to repair both the cartilage and the cells responsible for producing synovial fluid (chondrocytes).

Taken together, the CBD can help lower inflammation and treat pain, while the glucosamine and chondroitin sulfate help to restore cartilage tissue over time.

5. CBD & St. John’s Wort for Depression

Depression can be debilitating to our health, especially if allowed to persist for long periods.

CBD is a good option for treating depression primarily for its anti-inflammatory benefits. Neuroinflammation is a key driver of depression [8], but it’s not the only cause.

Most antidepressant medications work by increasing serotonin levels in the brain — something that CBD isn’t able to do.

However, another herb — St. John’s Wort (Hypericum perforatum) — can do this.

This herb works similarly to common SSRI medications used to treat depression [9]. It blocks the reuptake and breakdown of serotonin in the brain, causing levels to increase outside the neurons.

This ability to increase serotonin, combined with the powerful anti-inflammatory effects of CBD, provides a powerful combination for alleviating symptoms of depression.

Of course, always consult with your doctor before taking any supplements to treat depression, especially if you’re already taking antidepressant medications. Both CBD and St. John’s Wort may interact negatively with this type of medication — in which case, they should be avoided.

Bonus CBD Supplementation Tip

Grapefruit Juice to Prolong the Effects of CBD

CBD — like any other compound we consume — is eventually metabolized and deactivated by the liver.

The liver is an incredibly versatile organ. It can break down nearly any compound that enters the bloodstream thanks to a set of enzymes known as the cytochrome P450 isoenzyme complex.

Depending on the chemical structure of the compound being metabolized, different enzymes will step up for the job.

When it comes to CBD, the liver mainly relies on two enzymes — CYP3A4 and CYP3A5 [4].

Therefore, if we inhibit the activity of these enzymes, it will take much longer for the liver to break the CBD down.

There are a few things that can achieve this, but nothing as strong, or as readily available, like grapefruit juice [5].

This has led to a lot of people drinking grapefruit juice or taking grapefruit juice extracts, alongside their CBD supplementation — effectively lowering their required daily dose of CBD and providing long-lasting relief.

Cautionary Note: Grapefruit juice also inhibits other liver enzymes, so you should never take this supplement if you’re taking other medications as it may cause side effects. It’s especially important to avoid grapefruit juice if you are taking blood thinners or other medications to treat high blood pressure.

Key Takeaways: Supplements to Take with CBD

CBD is an incredible health supplement. It has a lot to offer a wide range of different medical conditions. However, like many other compounds, CBD is even better when combined with other herbs and supplements.

Choosing which supplements to combine it with depends on the symptoms you’re treating.

By leveraging the benefits of CBD alongside other supplements, we’re able to provide even greater benefits toward reversing, preventing, or alleviating symptoms.

This is the difference between a holistic approach versus a reductionist approach. Which one will you choose?

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5 Reasons Why CBD and Gaba Can Assist Sleep

CBD research shows how taking cannabidiol can have a positive effect on sleep. In this article, we will examine how GABA and CBD work together to create the perfect combination for tackling sleep-related issues.

This article covers all of the topics below. Click on each bullet point to skip to the relevant section.

  • What is GABA?
  • How to increase GABA levels?
  • What is CBD?
  • Will CBD get you high?
  • How to take CBD?
  • 5 reasons why GABA and CBD will promote better sleep
  • Where can I buy GABA supplements for sleep?

What is GABA?

GABA (Gamma-Aminobutyric acid) is a naturally occurring amino acid that works as a neurotransmitter, facilitating communication among brain cells. It is one of the most abundant neurotransmitters in the brain; in fact, over 40% of neurons have a GABA receptor. The primary role of this amino acid is to slow the activity of neurons in the brain and central nervous system. This process helps our brain shift into a lower gear and bring about more relaxation and calm.

How to Increase GABA Levels

Research shows a link between low levels of GABA and increased anxiety, high blood pressure and insomnia. These findings indicate that a GABA deficit is possible and balancing your GABA levels is vital to good health.

Can you get GABA naturally from food?

GABA isn’t readily available in natural food products. However, some fermented products, including yoghurt and kefir, contain the amino acid. Alternatively, some foods contain a substance called flavonoids, which influence how GABA works in the brain.

These products include:

  • Green, black and oolong teas
  • Red wine
  • Vegetables

What are flavonoids?

Flavonoids are a naturally occurring compound and are rich in antioxidant activity. A diet rich in flavonoids will assist your body in fighting off everyday toxins and decrease the risk of some chronic health conditions. The flavonoids in some foods will activate the GABA receptors and help regulate your body.

GABA as a supplement

GABA is also available as a supplement to treat anxiety, high blood pressure, pain-related issues and sleep problems. However, when taken alone, GABA supplements struggle to penetrate the blood-brain barrier. Consequently, this means that only a small amount of the supplement may make it to your brain and will have little effect. For the most effective results, researchers recommended taking an enhanced GABA supplement that does not inhibit the GABA receptor.

What is CBD?

CBD, also known as cannabidiol, is one of over one hundred compounds that come from the cannabis plant. Unlike its cousin, THC (Tetrahydrocannabinol), CBD is non-psychoactive and will not have intoxicating effects.

The cannabis plant goes through an extraction method to release the CBD and make it safe for consumption. It is then combined with a carrier oil, such as MCT or olive oil, to form the CBD oil you see on the market.

Will CBD get you High?

The short answer – no, CBD will not get you high.

One of the most common misconceptions around CBD is its ability to cause a ‘high’. The confusion stems from its association with the cannabis plant. In fact, cannabidiol comes from the hemp variation of the cannabis strain but does not have psychoactive abilities. Therefore, when CBD gets extracted from the plant, the intoxicating component, THC, gets removed. The varying extraction methods will affect the quality of the final product and how much THC is left. Considering this, we recommend looking for a company that is transparent about its CBD extraction process.

The quality and contents of CBD oil will differ from where you buy it, however, here at ULU, we guarantee our products contain less than 0.0005% of THC – virtually zero, hence why we pride ourselves on our premium quality.

The Different Types of Cannabidiol

As with the extraction process, different types of cannabidiol can affect the end product. If your product contains high levels of THC; it could work against the GABA receptors in your body and inhibit it, which will lead to little improvement in your sleep. Consequently, it’s essential to do your research about the type of CBD you’re taking and the extraction methods available.

CBD Isolate

CBD isolate is the purest form of cannabidiol and an ideal type for first-time buyers. Products with CBD isolate will not contain any of the other beneficial cannabinoids. This type of CBD is also an excellent option for anyone who has to take a drug test, such as professional athletes.

Full-Spectrum CBD

In full-spectrum CBD, the whole plant gets extracted, meaning it contains all of the natural cannabinoids and terpenes found in the hemp plant. With full-spectrum, you will be able to taste and smell the hemp. Lastly, this variation is a good option for amino acid and GABA supplements because the flavonoids in the hemp plant are still present and activate the GABA in our brains.

Broad-Spectrum CBD

Sitting in between full-spectrum and isolate, broad-spectrum CBD has trace elements of other beneficial cannabinoids (CBDa and CBG) but only a mild taste of the hemp plant.

How to take CBD?

CBD products come in many different forms, and depending on what you need it for, you may need a specific product.

Some CBD forms include:

  • Oil
  • Gummies
  • Capsules
  • Bath bombs
  • Topical treatments (such as creams and muscle rubs)

If you’re looking to treat sleep difficulties, our CBD and GABA oil is the best option for you because of its ability to enter the bloodstream and pass through the blood-brain barrier.

To read more about the different types of CBD head to our guide to CBD products.

5 Reasons Why CBD and GABA Can Promote Better Sleep

Now you know what GABA and CBD are, we will explore how these two potent compounds interact with our body to assist sleep.

1. CBD is a Natural Sleep Aid

Cannabidiol is a natural sleep aid because of the way it interacts with our endocannabinoid system (ECS). The ECS is a complex cell-signalling system within our bodies that helps to regulate sleep, mood, and other bodily functions. Furthermore, our bodies naturally contain cannabidiol, so added CBD would improve the functions of our ECS and help restore balance and harmony in our body, allowing us to sleep easier.

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Over the last few years, research has focused on how CBD affects sleep. In a study of 72 adults, 66.7% of patients reported improvements in their sleep within the first month. In addition, 79.2% of patients said their anxiety was reduced within the first month and remained low for the duration of the study. So in conclusion, CBD has been known to relax the mind and body and naturally aids sleep thanks to its ability to assist the ECS and balance our bodies.

2. GABA Helps you Fall Asleep Faster and Wake Up Refreshed

Research shows that higher levels of GABA put people in a non-REM state of rest for longer. This stage of sleep is known to use less energy and promotes calmer sensations such as slowed breathing and heart rate. Due to this change, participants reported a noticeable difference in their sleep. As a matter of fact, the increased time of non-REM sleep meant people would wake up feeling refreshed and energised. Moreover, the same study also demonstrated how quickly GABA gets absorbed into the body, hence it had a significantly strong effect on the early stages of sleep. Therefore, having added GABA supplements make it easier to fall asleep quicker.

3. GABA and its Affect on Blood Pressure

As our bodies prepare for sleep, there is a natural drop in blood pressure which helps us transition into rest. However, if you have a higher blood pressure than average, this can inhibit your ability to fall asleep and cause more sleep problems. Studies show GABA has a positive effect on this and can lower high blood pressure. Consequently, taking a GABA supplement will help in the progression to sleep and improve the quality of rest.

4. The Entourage Effect

There is an argument that when taking GABA supplements alone, they struggle to have a significant effect because it cannot break the blood-brain barrier and reach the brain. Despite that, when enriched with CBD, the abilities of both substances are enhanced, meaning that the added GABA can get to the brain and help promote better quality sleep.

When you’re looking for an enriched GABA supplement, make sure to do your research and choose one combined with pure CBD. If you’re taking a GABA supplement alongside a THC product, this can have the reverse effect and inhibit your GABA receptors. Instead of your supplement increasing your GABA levels, it will shut down your bodies ability to regulate stress and anxiety.

Here at ULU, we pride ourselves on our high-quality ingredients; that’s why we have a 0% THC guarantee and test our products with a third party, to give you complete peace of mind.

5. Reduces Anxiety and Presses the Pause Button on your Brain

When our brain goes into the stress response of ‘fight, flight, or freeze’, our brain produces a stress hormone called cortisol. When this process happens, it can negatively impact our bodies and minds – including our ability to fall asleep and stay asleep. After that, GABA and the GABA receptors in our bodies send a signal to your brain to stop the stress response and produce feelings of relaxation. It’s common for people with anxiety to have lower levels of GABA and not be able to regulate the stress response in a healthy way. Accordingly, when we experience higher levels of stress and low levels of GABA, this can lead to enhanced sleep problems.

The amino acid is also useful for calming our mind, especially when overstimulated with thoughts. When you reduce anxiety, it leads to improved sleep quantity and quality.

Where Can I Buy GABA Supplements for Sleep?

When treating conditions like insomnia, there are medications that you can take. However, these can come with substantial side effects such as hallucinations, which can negatively affect GABA levels. With supplements, you can safely increase your GABA levels and sleep better – they are ideal for helping you switch off before bed.

As we discussed earlier, some feedback shows taking GABA supplements alone are relatively ineffective. This ineffectiveness is due to the added GABA not being able to penetrate the blood-brain barrier, meaning only a small amount of the supplement will make it to your brain.

Nevertheless, GABA enriched with another component such as CBD, enhances its ability to break through that barrier and make it to the brain, resulting in a more reliable and effective product.

When these two powerful components are combined, you get a stronger boost and better sleep.

Here at ULU, we crafted a premium range of CBD and amino acid supplements, including our CBD and GABA oil. While GABA supplements aren’t new to the market, the combination of CBD and GABA supplements are relativity forthcoming.

Our CBD and GABA oil work to improve sleep thanks to its ability to reduce stress, pain, and enhance mental and physical performance. When combined, it creates an entourage effect . Meaning together the CBD and GABA have more substantial effects compared to being taken alone.

Get Shopping for CBD and Gaba Products

We hope this article has educated you on the beautiful benefits of GABA and CBD for sleep. You can read more about CBD and Sleep.

As you can see, taking GABA supplements for sleep is excellent – but taking one enriched with high-strength CBD is even better. We hope you enjoy browsing our premium range of amino CBD supplements.

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