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canabidiol

Klotz KA, Hirsch M, Heers M, Schulze-Bonhage A, Jacobs J. Effects of cannabidiol on brivaracetam plasma levels. Epilepsia. 2019;60(7):e74-e77. View abstract.

FDA and Marijuana: Questions and Answers. U.S. Food and Drug Administration Web site. Available at: https://www.fda.gov/NewsEvents/PublicHealthFocus/ucm421168.htm. Accessed: May 31, 2015.

Carlini, E. A. and Cunha, J. M. Hypnotic and antiepileptic effects of cannabidiol. J Clin Pharmacol 1981;21(8-9 Suppl):417S-427S. View abstract.

Side Effects

Long LE, Chesworth R, Huang XF, et al. A behavioral comparison of acute and chronic Delta9-tetrahydrocannabinol and cannabidiol in C57BL/6JArc mice. Int J Neuropsychopharmacol 2010;13(7):861-76. View abstract.

Malone DT, Jongejan D, Taylor DA. Cannabidiol reverses the reduction in social interaction produced by low dose Delta(9)-tetrahydrocannabinol in rats. Pharmacol Biochem Behav 2009;93(2):91-6. View abstract.

Lattanzi S, Trinka E, Striano P, et al. Cannabidiol efficacy and clobazam status: A systematic review and meta-analysis. Epilepsia. 2020;61(6):1090-1098. View abstract.

Consroe P, Sandyk R, Snider SR. Open label evaluation of cannabidiol in dystonic movement disorders. Int J Neurosci 1986;30(4):277-82. View abstract.

CBD has been touted for a wide variety of health issues, but the strongest scientific evidence is for its effectiveness in treating some of the cruelest childhood epilepsy syndromes, such as Dravet syndrome and Lennox-Gastaut syndrome (LGS), which typically don’t respond to antiseizure medications. In numerous studies, CBD was able to reduce the number of seizures, and, in some cases, it was able to stop them altogether. Videos of the effects of CBD on these children and their seizures are readily available on the Internet for viewing, and they are quite striking. Recently the FDA approved the first ever cannabis-derived medicine for these conditions, Epidiolex, which contains CBD.

CBD is commonly used to address anxiety, and for patients who suffer through the misery of insomnia, studies suggest that CBD may help with both falling asleep and staying asleep.

Is cannabidiol legal?

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Side effects of CBD include nausea, fatigue and irritability. CBD can increase the level in your blood of the blood thinner coumadin, and it can raise levels of certain other medications in your blood by the exact same mechanism that grapefruit juice does. A significant safety concern with CBD is that it is primarily marketed and sold as a supplement, not a medication. Currently, the FDA does not regulate the safety and purity of dietary supplements. So, you cannot know for sure that the product you buy has active ingredients at the dose listed on the label. In addition, the product may contain other (unknown) elements. We also don’t know the most effective therapeutic dose of CBD for any particular medical condition.

CBD is readily obtainable in most parts of the United States, though its exact legal status is in flux. All 50 states have laws legalizing CBD with varying degrees of restriction, and while the federal government still considers CBD in the same class as marijuana, it doesn’t habitually enforce against it. In December 2015, the FDA eased the regulatory requirements to allow researchers to conduct CBD trials. Currently, many people obtain CBD online without a medical cannabis license. The government’s position on CBD is confusing, and depends in part on whether the CBD comes from hemp or marijuana. The legality of CBD is expected to change, as there is currently bipartisan consensus in Congress to make the hemp crop legal which would, for all intents and purposes, make CBD difficult to prohibit.

A Prati-Donaduzzi possui em comercialização três apresentações do produto, sendo nas concentrações de 20 mg/ml, 50 mg/ml e 200 mg/ml. Os produtos são apresentados ao consumidor em forma de solução oral em frascos com 30ml. As diferentes concentrações ampliam a acessibilidade ao tratamento para diferentes patologias.

O Canabidiol Prati-Donaduzzi possui alta concentração do ativo. Na versão de 200 mg/ml contém 6.000 mg de Canabidiol, enquanto na de 50 mg/ml há 1.500 mg de Canabidiol e na de 20 mg/ml contém 600 mg.

A utilização de uma matéria-prima altamente purificada e a realização de todos os testes de qualidade necessários permite a segurança e garantia da qualidade lote a lote do Canabidiol Prati-Donaduzzi. O Canabidiol Prati-Donaduzzi carrega muita responsabilidade e o compromisso social de uma indústria brasileira.

A formulação do produto é realizada pela indústria farmacêutica, em seu parque fabril, localizado em Toledo, região Oeste do Paraná, assim como a logística de venda e distribuição, que foi ampliada pela parceria com as distribuidoras Profarma e Santa Cruz. Isso significa que as farmácias de todo o Brasil são atendidas.

É um fitofármaco (fármaco de origem vegetal) e a indicação terapêutica é determinada pelos profissionais médicos na prescrição. Sua venda está condicionada à apresentação de receituário tipo B (azul), de numeração controlada.