Chronic inflammation impacts 43 million Americans every year. It's a painful condition that has left many people with ongoing discomfort. Thankfully, the therapeutic properties of weed may offer some reprieve for those who are still looking for relief.
CBD-dominant marijuana strains are believed to be anti-inflammatory and may provide relief to some consumers, although more research is needed on this topic. Strains with anti-inflammatory properties tend to feature the dominant terpene myrcene. Popular examples of this type of strain include CBD OG, CBD Blue Shark, and CBD Kush . Use this list to discover the best marijuana strains for fighting inflammation and their effects.
Inflammation was induced by injection of 40 μL of a suspension of 1.5% w/v zymosan A (Sigma) in saline into the subplanter surface of the right hind paw of the mice. This was followed immediately by an injection of the sample intraperitoneally (10, 25, or 50 mg/kg). For injection, the terpenoids were dissolved in vehicle containing ethanol:Cremophore:saline at a ratio of 1:1:18. CBD was used as a positive control. Paw swelling and pain perception were assessed after 2, 6, and 24 h. Blood was collected after 24 h for analysis of TNFα serum levels.
Calibrated calipers were used to measure paw swelling (thickness) 2, 6, and 24 h after injection of zymosan. 20
Induction and treatment of paw inflammation
Introduction: Cannabinoids are well known to have anti-inflammatory effects in mammalians; however, the Cannabis plant also contains other compounds such as terpenoids, whose biological effects have not yet been characterized. The aim of this study was to compare the anti-inflammatory properties of terpenoids with those of cannabidiol (CBD).
Different chemotypes of cannabis have a distinctive composition of terpenoids. These essential oils do have anti-inflammatory and antinociceptive activities that vary according to their composition, but they had no effect on TNFα titers. None of the essential oils was as effective as CBD. We suggest that terpenoids may be used to diminute acute inflammation effect, whereas the cannabinoids to inhibit chronic inflammation symptoms.
Similar to ROI inhibition, the T1 and T2 essential oils significantly suppressed LPS-induced NO • production by RAW macrophages when applied at a concentration of 40 μg/mL ( Fig. 3 ). Lower concentrations of T1 and T2 had almost no effect. The T3 essential oil had barely any effect at the concentrations used.