The most comment side effects of CBD include drowsiness, gastrointestinal issues, dry mouth, reduced appetite, nausea, and interaction with other medications. Those are outlined in detail below.
Steven Gans, MD is board-certified in psychiatry and is an active supervisor, teacher, and mentor at Massachusetts General Hospital.
“Since discovering the endocannabinoid system (ECS) in the body in the 1990s, CBD has been researched more extensively. The ECS is a central regulatory system restoring normal balance and homeostasis in a range of human physiologic systems throughout the body and brain and has cannabinoid receptors and chemicals in its function,” explains Dr. Matharu-Daley.
It’s important to point out that CBD is not regulated by the FDA and therefore dosages might not be accurate. It’s also difficult to know what an appropriate dose is the first time you try a new product.
CBD is one of the many chemical compounds that is found in the cannabis plant—referred to as cannabis sativa. There are two primary parts of the plant that humans use. One is THC, or Delta-9-Tetrahydrocannabinol, and the other is CBD. Though they’re from the same plant, THC and CBD are quite different from each other.
Early research on CBD for the treatment of insomnia suggests that it may be effective. Additional studies are needed.
Other oral forms of CBD are edible gummies and capsules. Topical CBD may also be a lotion, cream, or balm.
CAUTION: CBD should not be used with medicines that are prescribed to control seizures.
Does Oral CBD Help with Pain?
CBD should be used according to the manufacturer’s instructions. A person should read and follow the label carefully. Use no more than instructed. Using more may increase the chance of side effects or it may cause other problems.
There are also studies of oral, topical, and inhaled CBD for use in many other conditions including: dystonia (movement disorder), Fragile X syndrome (rare genetic disorder), graft-versus-host disease (bone marrow transplant rejection), multiple sclerosis (MS), opioid withdrawal, schizophrenia, and smoking cessation. CBD is also used to alleviate Parkinson’s symptoms, but there are some studies that advise against it.
Many studies of CBD, including its side effects, are in their early stages. Most people tolerate CBD well.
A recent Gallup poll found 1 in 7 adults in the U.S. have used CBD. Does it help?
You want to replace a current treatment with CBD. (Very important!) We absolutely love CBD and have heard from countless enthusiasts who’ve been able to cut back on pharmaceuticals with the assistance of CBD. That said, please do not substitute any current medications or prescribed treatments with CBD unless it’s with the approval of a medical professional. Our hope is to provide you with extra support, not to replace the supports you already have in place. Life can be difficult to manage alone, and in times of need, we encourage you to seek all the medical and emotional assistance available.
You’re surrounded by germs. (Not enough evidence) Some people hypothesize that CBD’s excellent immune-system soothing capabilities could accidentally let a few stray germs slip past your immune system’s defense. Scientists have tested this by exposing mice to the bacterium that causes Legionnaires’ disease and measuring their ability to fight the infection. Although moderate doses of CBD didn’t impair their immune systems, they were worse off on high doses equivalent to 1,000 mg for a 150lb person . If you’re currently taking higher doses of CBD and also sharing space with a bunch of coughing people, it might be a good idea to temporarily decrease your CBD dose.
Although CBD might be a new molecule to you, scientists have been studying it since the 1970’s, alongside its infamous sister molecule, THC. For the past few decades, lawyers, doctors, patients and politicians have all been pitting the medical potential of cannabis against its risk for recreational abuse. But all the while, evidence has been mounting that CBD offers similar — if not better — medical benefits without the downside of a “high” from THC.
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In the absence of definitive, slam-dunk clinical evidence, what the general CBD community does have to work with is a great deal of preliminary scientific evidence from laboratory experiments, animal models and case studies. Hundreds of scientific papers are published annually on cannabidiol, and the vast majority continue to point at CBD’s safety & efficacy for a wide range of conditions. This preliminary scientific evidence — from animal studies and human case studies — is what gets the ball rolling towards clinical trials.
Clinical trials give patients high-quality, safe products which contain a reliable quantity of CBD. The Epidiolex side effects are ones you might expect from a high dose of a very pure product. On the other hand, because the supplement industry in the US isn’t heavily regulated, if you purchase CBD from dishonest or potentially unsafe manufacturers, you might experience very different side effects. In fact, when scientists recently tested a variety of publicly-available CBD products, only 31% were accurately labeled .
Side effects based on high-dose clinical trials
These trials will double the number of preexisting clinical trials that have been carried out for cannabidiol, and it’s just the beginning. Will some of the promising benefits of CBD prove wrong when tested clinically? Most likely. People are currently trying to treat countless conditions with CBD, and it’s likely that a few of them might not be any more effective than placebo when tested with clinical trials.