Unlike the FDA-approved CBD drug product, unapproved CBD products, which could include cosmetics, foods, products marketed as dietary supplements, and any other product (other than Epidiolex) making therapeutic claims, have not been subject to FDA evaluation regarding whether they are effective to treat a particular disease or have other effects that may be claimed. In addition, they have not been evaluated by the FDA to determine what the proper dosage is, how they could interact with other drugs or foods, or whether they have dangerous side effects or other safety concerns.
The FDA is actively working to learn more about the safety of CBD and CBD products, including the risks identified above and other topics, such as:
Unproven medical claims, unsafe manufacturing practices
We are aware that there may be some products on the market that add CBD to a food or label CBD as a dietary supplement. Under federal law, it is illegal to market CBD this way.
In addition to safety risks and unproven claims, the quality of many CBD products may also be in question. The FDA is also concerned that a lack of appropriate processing controls and practices can put consumers at additional risks. For example, the agency has tested the chemical content of cannabinoid compounds in some of the products, and many were found to not contain the levels of CBD they claimed. We are also investigating reports of CBD potentially containing unsafe levels of contaminants (e.g., pesticides, heavy metals, THC).
In addition, CBD can be the cause of side effects that you might notice. These side effects should improve when CBD is stopped or when the amount used is reduced. This could include changes in alertness, most commonly experienced as somnolence (sleepiness), but this could also include insomnia; gastrointestinal distress, most commonly experienced as diarrhea and/or decreased appetite but could also include abdominal pain or upset stomach; and changes in mood, most commonly experienced as irritability and agitation.
Not only does THC cause the mouth to dry out, it can also cause dry, red eyes. It’s the classic, telltale giveaway that has made eye drops a natural companion for discreet cannabis consumers. But what causes it, and are eye drops the only cure?
Remember to dose low and keep plenty of water (and maybe some chewing gum) on-hand in the event that cottonmouth strikes.
Indica strains have long been associated with sedative effects, so we recommend sativa or high-CBD strains for daytime use. You may also consider trying a cannabis-infused coffee or tea, or pairing them to help lift out the lethargy.
It may be, in part, due to the fact that smoke can irritate the eyes, but other consumption methods can also cause dry, red eyes. THC is known to lower blood pressure and dilate blood vessels in the eyes, leading to redness. Though less likely, an allergy to cannabis can also cause red eyes.
Better known as the dreaded “cottonmouth,” high-THC cannabis can also make your mouth drier than the Sahara Desert. Believe it or not, there are cannabinoid receptors in our saliva glands. THC mirrors a naturally occurring chemical called anandamide, which binds to these receptors to decrease saliva production. THC, with its high affinity toward these receptors, exaggerates that effect much to our dismay.
States that have legalized marijuana for recreational or medical consumption have laws in place that make it illegal to drive under the influence of marijuana; review each states law carefully.
Note: some states may have passed laws but still may be in the process of finalizing procedures and rules surrounding distribution.
Safety of cannabis
People who use large quantities of cannabis may become sedated or disoriented and may experience toxic psychosis — not knowing who they are, where they are, or what time it is. High doses may also cause fluctuating emotions, fragmentary thoughts, paranoia, panic attacks, hallucinations and feelings of unreality.
Cannabis may increase the effects of other drugs that cause drowsiness, including:
Multiple US states, territories and the District of Columbia have legalized the use of recreational marijuana; however, not all of these states permit the commercial production or retail sale of recreational cannabis. Check with each state for rules surrounding use of recreational marijuana.