CBD oil may also increase liver enzymes (a marker of liver inflammation). People with liver disease should use CBD oil with caution, ideally under the care of a doctor who can regularly check blood liver enzyme levels.
CBD oil contains CBD mixed with an inert carrier oil, such as coconut oil or hemp seed oil. The bottled oil, called a tincture, is sold in various concentrations. There are also CBD capsules, CBD gummies, and under-the-tongue CBD sprays.
According to a 2012 study in the Journal of Experimental Medicine, rats injected with inflammatory chemicals in their hind feet experienced less inflammation and neuropathic pain when treated with an oral dose and spinal injection of CBD.
Possible Side Effects
Clinical research has shown that CBD oil can trigger side effects. Severity and type can vary from one person to the next.
In addition, the stroke volume (the amount of blood remaining in the heart after a heartbeat) was significantly reduced, meaning that the heart was pumping more efficiently.
In an analysis of 14 published studies (nine involving animals and five involving humans), scientists with the University of Montreal concluded that CBD showed promise in treating people with opioid, cocaine, or psychostimulant addiction.
CBD oil may benefit those with drug addiction, suggests a 2015 review of studies published in Substance Abuse.
Several smalls studies have investigated using CBD to relieve symptoms of Parkinson’s Disease, with mostly encouraging results. For most studies, there were no differences across groups with regards to movement-related outcomes; however, groups treated with CBD 300 mg/day had a significantly improved well-being and quality of life as measured by the Parkinson’s Disease Questionnaire [PDQ-39]). 15
Conclusion: CBD may help with depression but more trials are needed.
Conclusion: CBD is unlikely to be effective by itself for nausea and vomiting. The combination of THC and CBD does seem to be effective for nausea and vomiting.
8. Parkinson’s Disease
A case series of 47 people with multiple sclerosis reported improvements in pain, walking, and muscle spasms with a combination of CBD and THC. 15
Other trials of 300 mg of CBD in people with anxiety or depression showed that CBD appeared to preserve sleep architecture, meaning it was unlikely to have any negative effects on sleep quality. 10
In June 2018, the FDA approved Epidiolex (a plant-based formulation of CBD) to treat seizures for people 2 years of age and older with Dravet syndrome and Lennox-Gastaut syndrome (LGS), which are two rare forms of epilepsy.
Anxiety scores decreased in a large case series of 72 patients, with 57 patients (79.2%) reporting decreased scores within the first month after CBD treatment. 9
For students with generalized social anxiety, a four-minute talk, with minimal time to prepare, can be debilitating. Yet a small experiment in the journal Neuropsychopharmacology found that CBD seemed to reduce nervousness and cognitive impairment in patients with social anxiety in a simulated public speaking task.
More than 60 percent of CBD users were taking it for anxiety, according to a survey of 5,000 people. Does it help?
Does CBD work?
But without clinical trials in humans, psychologists say CBD’s effect on depression is still a hypothesis, and not an evidence-based treatment.
By Dawn MacKeen
Many soldiers return home haunted by war and PTSD and often avoid certain activities, places or people associated with their traumatic events. The Department of Veterans Affairs is funding its first study on CBD, pairing it with psychotherapy.