Mean peak CBD plasma concentrations at 3-4 hours post-dose with Sativex at a low dose (5.4 mg of Delta-9 THC and 5.0 mg of Cannabidiol) were 1.6 +/- 0.4 ng/mL and at a high dose (16 mg of Delta-9 THC and 15 mg of Cannabidiol) were 6.7 +/- 2.0 ng/mL.
Following high dose 400 and 800 mg oral synthetic CBD in corn oil administration, mean peak CBD plasma concentrations occurred within 1.5-3 hours post-dose and were 181.2 +/- 39.8 and 221.1 +/- 35.6 ng/mL, respectively.
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
The ratio of blood to serum or plasma concentration is unknown for this analyte.
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THE MAYO CLINIC WEIGHS IN ON CBD – OFFERS DOSAGE SUGGESTIONS.
8 thoughts on “Mayo Clinic Weighs in on CBD – offers Dosage Suggestions”
Thank you, Delano!
If I were you, I’d use our Body Creme 525 CBD:CBG. It’s what I use. It offers quick relief from arthritis pain, and it’s a topical, offering quicker results. I hope this helps! -Joan
Hi Diana, I don’t know where you’ve purchased this item from. I hope you asked for the lab results of what’s in that bottle. Assuming you did, I would start with figuring out the CBD dosage per dose. It’s a 300 mg Tincture bottle, if it’s in a one ounce bottle, then most likely, there are 30 doses per bottle.’check the label. If those assumptions are correct, then one dose is only 10 mg. That’s less than my customers give their pets.
Most adults use 500-1000 mg Tinctures.
Even though CBD is legally and medically murky, consumers can take a few strategies to minimize risk. Scrutinize labels, buy organic, and purchase from a certified medical dispensary or company that has a certificate of analysis. This certificate means an independent lab has studied the product and certified what it does and does not contain. Find out how and where the hemp plant from which the CBD product is derived is grown, Mauck says. Make sure it is grown legally and not from a foreign source.
Despite these challenges, Mauck stresses that it’s important for health professionals to be as current on the research and developments as possible. She and her co-authors designed the review to be a clinical tool to help physicians more effectively advise patients on CBD use.
Ultimately, everything we do comes with a risk, Mauck says. With time and more research, the potential risks and benefits will become clearer.
Snake Oil or Miracle Cure?
It’s hard to know exactly what you’re getting. A 2017 review of 84 CBD products published in JAMA found that only a third of the products accurately labeled CBD and THC levels: most over-labeled CBD and under-labeled THC.
The review also looked at potential negative effects. The review found potential risks of CBD — liver damage, mislabeling, and drug interaction. Anecdotally, patients also report side effects of weight loss, diarrhea, and dizziness from CBD use, Mauck says. But potential side effects depend on how and how much you take in. Inhale CBD, eat it, or spread CBD lotion on your body, and the effects can vary.
“Because CBD is not controlled, basically, it’s anybody’s guess what can be in these. And so they can claim that it’s 30% cannabidiol and otherwise pure. But if it’s not independently tested, it may have other pesticides, toxins, heavy metals,” Mauck says.
The Mayo Clinic review emerged after Mauck and her Mayo Clinic colleagues were barraged with questions from patients about the safety and efficacy of CBD. Other patients weren’t consulting their doctor about CBD at all.