A recent study by researchers affiliated with Colorado State University has found that water-soluble cannabidiol products provide the best absorption of CBD, shedding new light on best practices for consumers seeking the benefits of the popular cannabinoid. Bioavailability refers to the degree and rate at which a substance is absorbed into your bloodstream. Read more on how dosage and consumption method can affect how much cannabis your body uses. From taking CBD oil sublingually to using suppositories, each type of CBD product is absorbed by your body differently. Find out more about bioavailability.
New Study Suggests Water-Soluble Cannabidiol Products Provide Best CBD Absorption
A recent study by researchers affiliated with Colorado State University has found that water-soluble cannabidiol products provide the best absorption of CBD, shedding new light on best practices for consumers seeking the benefits of the popular cannabinoid. The study, which was published last month in the peer-reviewed journal Nutrients, also explored the effects that cannabidiol has on digestion and determined that CBD products are best consumed with food for maximum absorption, among other findings.
The research, which was conducted in conjunction with Colorado State University’s Department of Health and Exercise Science, compared the absorption of five different CBD formulations in 14 male test subjects. Products studied included CBD diluted in medium-chain triglycerides (MCT) coconut oil, CBD isolate, and three different water-soluble CBD ingredients. The goal of the study was to document how each of these formulations of CBD entered and left the bloodstream and at what rate. Additionally, the study profiled how the formulations interacted with liver functionality and if there was evidence that food intake and metabolism were affected by the products.
New research shows that taking water-soluble cannabidiol products with food provided the best . [+] absorption of CBD.
Water-Soluble CBD Had Best Absorption
The study found that water-soluble CBD preparations displayed superior pharmacokinetics compared to oil-based CBD. One of the water-soluble CBD preparations used in the study was created using proprietary technology from NextEvo Naturals, which has proven to significantly improve bioavailability. John McDonagh, CEO of the company, said that the research sheds new light on how consumers can get the most out of the CBD products they take.
“While the potential health benefits of CBD have been widely publicized, this new data suggests consumers should be very aware of the pharmacokinetic differences between commercial CBD formulations, for example, how the CBD you are taking gets absorbed into the body,” McDonagh said in a statement from NextEvo. “We set out to prove that our product formulations may actually be able to offer the many benefits of CBD because they enter the bloodstream quickly and efficiently.”
The results of the study, which NextEvo notes have not been evaluated by the U.S. Food and Drug Administration, show a more than 500% variance in maximum blood concentration achieved between water-soluble CBD ingredients compared to oil-based formulations and unformulated CBD isolate. The variance represents a significant difference in the body’s ability to absorb and process CBD, which is necessary to reap the potential health and wellness benefits of the cannabinoid.
Best Travel Insurance Companies
Best Covid-19 Travel Insurance Plans
Taking CBD With Food Increases Absorption
The results also showed that consuming water-soluble CBD with food greatly increases the body’s absorption of CBD and modifies early insulin and triglyceride responses. Six hours after consumption, CBD concentration in the bloodstream was three times higher when consumed with food compared to taking the product after fasting. David Chernoff, MD, chief medical officer at NextEvo, says that the research revealed CBD’s potential positive effect on insulin and triglyceride levels.
“Our study results show that within 30 minutes after eating a meal, CBD appeared to lower insulin and triglyceride levels. The exact mechanism of how CBD impacts insulin levels and triglyceride levels is unclear as the CBD levels 30 min post-meal are very low,” Chernoff writes in an email. “What one can infer from these findings is that CBD may have a favorable effect on how fats and sugars are metabolized after a meal so CBD might be beneficial for supporting healthy glucose and lipid metabolism.”
Researchers have long debated if eating a meal or fasting could affect CBD’s absorption into the bloodstream. Some have found that it helps to eat when taking oil-soluble CBD, but the new research suggests that taking water-soluble CBD products with food will provide the most benefit.
“We’ve found that the best way for consumers to take CBD is in a product containing a water-soluble formulation with a meal. This allows the body the opportunity for maximum absorption into the bloodstream,” writes Chernoff. “The more CBD the body absorbs, the more likely the consumer is to experience CBD’s potential benefits.”
CBD is available in a variety of product formulations.
“This is one of the first studies to examine the potential benefits CBD has on digestion and whether it should be administered with food,” NextEvo wrote in a statement about the research. “The study provides significant evidence that consuming CBD with food alters the dynamics of CBD metabolism and increases systemic availability, favorably modifying early insulin and triglyceride responses.”
The research also revealed new evidence on the safety of CBD. The study showed that CBD taken at average doses, in this case, 30mg per dose, does not evoke physiologically relevant changes in markers of liver function, suggesting that CBD probably does not represent a risk to the liver.
Potential limitations of the study identified by the researchers include a small sample size and the fact that all test subjects were male, although the authors wrote that they “have no reason to suspect the potential for sex differences.”
A report on the study, “Cannabidiol and Cannabidiol Metabolites: Pharmacokinetics, Interaction with Food, and Influence on Liver Function,” was published online by the journal Nutrients in May.
Most THC and CBD oil goes to waste in your body—here’s why
If you knew that only 6% of your CBD gummies would enter your bloodstream to do their job, would you still purchase them? Amid the current frenzy surrounding cannabis and its therapeutic benefits, it’s easy to gloss over the bioavailability of cannabis products.
Bioavailability refers to the degree and rate at which a substance is absorbed into your bloodstream to be used where needed. Physiological processes and consumption methods can affect cannabis absorption, rendering its effects somewhat hit-and-miss.
It’s critical to get clued up about bioavailability in order to maximize the medicinal potency of cannabis. The more bioavailable your cannabis, the lower the quantity of the plant you need to reap its benefits.
What factors influence cannabis bioavailability?
The surge in cannabis popularity can be partly attributed to the range of consumption methods available. Edibles and tinctures can have less of the stigma traditionally associated with joints. However, when cannabinoids such as CBD and THC are ingested in oil form—oil is also used to make edibles—their bioavailability becomes compromised.
CBD and THC oils resist absorption into the bloodstream because the human body is up to 60% water . Basic science—and salad dressing—dictates that oil and water do not mix, and the same is true for cannabis oil and the human body.
“Cannabinoids are fat-loving molecules and have to traverse a cellular environment that is aqueous or watery,” explains Dr. Patricia Frye, a member of the Society of Cannabis Clinicians and chief medical officer at Hello MD . When cannabis is consumed as an oil, the onset of effects can become delayed and bioavailability limited.
Another phenomenon that limits oil-based cannabis extracts from reaching the bloodstream is the first-pass effect. When cannabis is ingested orally, it is absorbed in the gastrointestinal tract and transported via the portal vein to the liver, where it is metabolized. As a result of this process, only a limited quantity reaches the circulatory system. Since cannabis oil is often taken orally, its efficacy can be hindered.
Are some cannabinoids more bioavailable than others?
There has been some investigation into CBD, THC, and less into cannabinol, or CBN. Studies have shown that the bioavailability of cannabinoids depends on the method of delivery.
When applied as a topical ointment or transdermal patch, CBD can penetrate the tissue ten times more effectively than THC. The same is true of CBN.
THC, however, is more bioavailable than CBD when administered orally or delivered via the lungs. A clinical study found that concentrations of THC in the bloodstream appeared 30-50% higher than CBD following oral delivery as a sublingual spray.
However, the bioavailability of THC is still limited when consumed orally, averaging only 4-12%. When smoked or vaped, the bioavailability of THC leaps to an average of 30%.
Which methods of cannabis consumption optimize bioavailability?
Some of the most common and convenient cannabis products, such as capsules, soft gels, tinctures, and edibles, limit bioavailability due to the first pass through the liver. “With edibles, absorption is slow, unpredictable, and highly variable,” says Frye. “Only about 6% of the dose is absorbed. The onset of action can be as long as 6 hours; it’s very easy to take too much, and the effects can last as long as 20 hours!”
Oral administration lasts longer than smoking, eliminating the need for frequent dosing. Oral methods also avoid irritation to the airways and the risk of malignancies associated with smoking or vaping.
That said, inhaling cannabis guarantees increased bioavailability because molecules are transported by vapor particles directly to the alveoli in the lungs. This allows cannabinoids to rapidly enter the bloodstream without being metabolized by the liver.
Another lesser known method of administration is intranasal delivery, which enables cannabinoids to be easily absorbed with a rapid onset of 10 minutes or less. “Intranasal methods are highly bioavailable at 34-46%,” says Frye. “It’s a particularly helpful mode of delivery for patients who are having a seizure or for patients trying to abort an impending seizure or migraine.”
Transdermal patches can be super effective at targeting localized or systemic pain. They allow for a steady infusion of active ingredients to the delivery site, so the patient is unlikely to experience spikes of THC in the bloodstream.
Finally, nano-emulsions and micro-emulsions can dramatically increase the stability and bioavailability of cannabinoids. These novel formulations use nanotechnology to offer up to 100% bioavailability. Frye cautions, however, that the research is still scarce. “We don’t know the full extent of how these manipulations affect cannabinoid activity at the cellular level,” she says.
What tips or tricks can help increase bioavailability?
One method that boosts the absorption of edibles is to combine cannabis product with fats. Frye recommends combining edibles or tinctures with healthy fats such as guacamole, hummus, or dark chocolate. If you’re feeling less virtuous, however, ice cream works as a treat. The same goes for alcohol-based tinctures.
For those who smoke or vape, bioavailability can be enhanced by minimizing sidestream loss and increasing the number of puffs. “Using a desktop or handheld vaporizer with flower will eliminate sidestream losses,” Frye advises. If you think you get more bang for your buck by holding your breath, think again. “There is no evidence supporting holding one’s breath for more than 10 secs,” says Frye.
Some final words of advice from Dr. Fyre, for those looking to optimize cannabis bioavailability: “The most cost-effective way to use cannabis is not to use more than you need. Less is more,” she says. Due to its biphasic nature, excessive dosing may exacerbate the symptoms you’re trying to alleviate.
In some CBD products, most of the CBD you consume will be destroyed before it reaches your bloodstream. How much survives for your body to utilise, is known as bioavailability. Bioavailability can be increased or decreased depending on how you take it.
Understanding how ‘bioavailable’ a product is, gives you valuable insight into how effective it will be.
What is bioavailability?
The bioavailability of any product refers to the amount of the active ingredient that will reach your bloodstream once you’ve consumed it. Once it’s been absorbed into your blood, it can be transported around your body to be used in your cells and tissues.
The bioavailability most often depends on the type of product and how it is been taken. Most methods of taking CBD only allow a limited amount of cannabidiol to reach your bloodstream. Some is broken down on the way or lost through other bodily processes.
If CBD were injected directly into your blood vessels, the bioavailability would be 100% because the full measure could be used in your body. Most other methods of taking CBD involve longer journeys to reach your blood resulting in a lower portion surviving.
Please note: We do not recommend that you inject CBD under any circumstances.
Bioavailability offers a useful way of estimating how effective a product might be. If it is highly bioavailable, more CBD can be used. Products with low bioavailability will deliver a small amount to your system and will need to be taken in larger amounts to produce a potent effect.
CBD absorption: fast facts
- CBD can be absorbed sublingually, through the skin, orally, rectally and inhaled.
- The most bioavailable form of CBD is an e-liquid/vape juice. Up to 56% bioavailability.
- You can make CBD more bioavailable by consuming it with a fat such as MCT oil.
- CBD can be absorbed in as little as 10 minutes when inhaled. Absorption can take up to two hours if eaten.
Bioavailability of different CBD products
There are hundreds of different CBD products to choose from, but they are all likely to be used in one of five ways : eaten, inhaled, absorbed under your tongue, inserted rectally or applied to your skin.
Each method transports CBD into your body but has a different rate of absorption. Different types of product deliver varying percentages of the original measure to your blood. The time it takes for you to feel any effect is likely to be different too.
The most efficient method for CBD absorption is to inhale the vapour using a vaporiser, which can deliver up to 56% of each measure to your bloodstream. This is a significant improvement compared to the 4-20% that is absorbed when you eat CBD.
CBD bioavailability chart
Uptake into your bloodstream
Time to take effect
1. Swallowed / ingested
30 minutes – 2 hours
2. Sublingually (under the tongue)
4. Inhaled or vaporised
5. Topically (rubbed into the skin)
Can be up to 45% but stays localised (enters local tissue & small blood vessels only).
1. CBD drinks or edibles
Any CBD product that is eaten or drunk must pass through your digestive system and your liver. This process has significant waste which is why only 4-20% of the CBD is available for use in your body.
Although you need to use more significant amounts of CBD to get the effect you want, these products are still popular. Capsules, drinks, edibles are convenient, discreet and can be flavoured to disguise the taste of the hemp extract.
2. CBD drops held under your tongue
Holding CBD under your tongue allows it to be absorbed across the thin membrane directly into the blood vessels. This means that it isn’t broken down in your digestive system, so there is a more significant amount available for use.
This method is most effective with liquid products like oils or tinctures. The desired number of drops is held under your tongue for 1 to 3 minutes and then swallowed. This can result in up to 35% bioavailability which is significantly better than just swallowing it.
The drawback with this method is that some products are hard to place under your tongue accurately and holding CBD in your mouth can produce an intensely bitter flavour. Finding a product with an accurate dropper or standing in front of a mirror to apply the drops can make it easier to deliver a precise measure. Also, holding oil under your tongue dulls the intensity of the flavour compared to holding it in your mouth as usual.
3. CBD suppositories inserted rectally
Because a large number of blood vessels in your rectum are close to the surface, CBD suppositories can have a bioavailability of up to 50%. However, products that can be used in this way aren’t easy to find and most people prefer not to use suppositories if there are other options available.
4. Vaporised or inhaled into your lungs
Vape oils, e-liquids and the dry herb are turned into tiny airborne droplets in a vaporiser. They can then be inhaled, drawing the CBD particles into your lungs. Then they cross the thin mucus membrane into your lung’s blood supply.
Your lungs provide a surface area of up to 75 square metres, which makes absorption into your blood quick and easy. The blood that passes through them picks up the CBD, travels to your heart and then around your body before it passes through the liver. This results in a large portion of each inhalation being available for use in your body.
CBD products burnt and smoked
Smoking CBD uses combustion to release particles that can be inhaled. The bioavailability can reach 31%, but you will also be inhaling other by-products (e.g. carcinogens) in the smoke. Also, when hemp or CBD flower burns, some of the cannabinoids are destroyed in the combustion resulting in it being far less efficient than vaping.
5. Rubbing CBD into your skin
Rubbing CBD into your skin is best when you’re aiming to target a specific area. A small amount may reach your bloodstream but not enough to provide any noticeable whole-body effects. Topical CBD is often added to skin care products or rubbed into joints and muscles.
Ways to increase bioavailability
To ensure you get the most out of every CBD product, there are some easy ways to boost the amount that reaches your blood:
Hold drinks and edibles under your tongue before swallowing
If you’re consuming CBD in a drink, oil, capsule or gummy, hold it under your tongue for 1 to 3 minutes before swallowing it. Biting open a soft gel capsule first will release the contents and increase the likelihood they can be absorbed sublingually. Gummies or other soft edibles can be vigorously chewed and then held under your tongue for better bioavailability.
Take CBD with a fatty meal
CBD dissolves well in fats so if you eat it combined with fat or follow it up with a fatty meal. It’s been found that more will survive the passage through your digestive system. Studies found that compared to taking CBD on an empty stomach, taking it with fat could increase the amount in your body by four times.
Choose water-soluble CBD products
Water soluble CBD is likely to provide a better bioavailability than those made with oil. It is specially prepared to pass quickly across your gut wall and miss out the first stage of digestion. It’s still broken down to some degree, but studies have found that the resulting concentration in your blood is higher than with standard oil preparations.
CBD affects each person in a slightly different way but knowing how much of each measure will reach your blood for use in your body, will help you to make better-informed decisions about what to buy and how to use it.
Vaping or holding CBD under your tongue are the best ways to get CBD into your system and as a result, are likely to be more cost-effective than other methods.
Join us to get updates and special deals monthly:
Janelle is a lifestyle and cannabis writer based in Portland, OR. An expert on all things cannabis and CBD, you can find her work featured in publications like Leafly, Forbes and DOPE Magazine. She’s also an aspiring filmmaker, an avid Nutella addict and enjoys cooking long, fancy meals on the daily.