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cbd oil dopamine

Clinical trials allow us to draw conclusions about the safety and effectiveness of potential therapeutic agents in humans, while animal studies and in vitro experiments allow researchers to explore their biological actions in greater detail. However, because the latter class of studies are not conducted in humans, the results don’t always lead to the clinical application that we hope for—the majority of drugs that start in human clinical trials never become approved. Nonetheless, animal studies provide us with a strong foundation of biological knowledge, and are where the initial breakthroughs in research are made.

CBD is famous for the promise it holds for treating treatment-resistant forms of childhood epilepsy. A number of clinical trials, testing the efficacy of CBD in human epilepsy patients, are currently underway. But there is also evidence, mainly from animal studies and in vitro experiments, that CBD may have neuroprotective, anti-inflammatory and analgesic (pain-relieving) properties, and potential therapeutic value in the treatment of motivational disorders like depression, anxiety, and addiction.

Why does THC get you high but not CBD?

CBD’s therapeutic potential with respect to addiction also extends to the serotonin system. Animal studies have demonstrated that CBD directly activates multiple serotonin receptors in the brain. These interactions have been implicated in its ability to reduce drug-seeking behavior. CBD’s influence on the serotonin system may also account in part for its anti-anxiety properties, which have been robustly demonstrated across both human and animal studies.

Given that these possibilities come mainly from animal studies, more research will be needed before we can think seriously about human applications.

Brain receptors are not only sensitive to neurotransmitters produced naturally within the brain, like dopamine or serotonin, but also chemical messengers produced outside the body, such as plant cannabinoids like THC or CBD. So when you ingest an edible or inhale some vapor, you’re allowing compounds originally produced by a plant to enter your body, travel through your bloodstream, and enter your brain. Once they arrive, these plant-derived compounds can influence brain activity by interacting with receptors on neurons. But they don’t interact with all neurons, just the ones that have the appropriate receptors.

Dopamine doesn't just activate the pleasure centers in the body. It's also responsible for the regulation of other functions such as:

CBD also has an impact on numerous non-cannabinoid receptor systems of the brain. It interacts with several receptors that are sensitive to many drugs and neurotransmitters. CBD raises the levels of anandamide in the brain. This is one of the naturally occurring cannabinoids found in the body. Anandamide helps in the regulation of other chemicals in the brain, which includes dopamine and serotonin. Through this effect, it helps to increase the level of dopamine in the body. CBD also stimulates the adenosine receptor to encourage the release of glutamate and dopamine neurotransmitters. Through its interaction with dopamine receptors, it helps to raise dopamine levels and regulate cognition, motivation, and reward-seeking behaviors.

CBD doesn’t have a direct influence on dopamine levels in the body. It acts on the 5-HT1A receptors present in numerous brain regions, specifically the pleasure areas where dopamine activity takes place.

CBD and Dopamine

Dopamine is what activates the brain's pleasure centers. CBD oil can alter dopamine levels in the body to offer a range of benefits and influence behavior.

Neurotransmitters are responsible for the communication of messages between neurons. An imbalance in the level of neurotransmitters in the body can lead to several neurological disorders. Dopamine is one such neurotransmitter produced by two main regions of the brain:

Despite being a cannabinoid, high-quality CBD doesn’t interact directly with CB1 and CB2 receptors. In fact, its interactions help in reducing the extreme effects of THC. It also raises the body’s level of naturally produced cannabinoids through inhibition of the enzymes that break them down. CBD also interacts with opioid receptors to regulate the perception of pain in the body.

Deficiency in the body’s dopamine levels can result in several disorders, apart from just having an impact on one’s mood. Parkinson’s disease is the result of degeneration of neurons that secrete dopamine in the substantia nigra. Attention Deficit Hyperactivity Disorder (ADHD) is also associated with a drop in dopamine activity, making concentration and focus difficult. Depression is another mental health disorder that can result from low levels of dopamine in the body. This can result in loss of motivation as well as reduced pleasure experienced from daily activities. Low dopamine levels in the body are also likely to lead to greater struggles with addiction.

Parkinson’s disease comes with a range of symptoms, many of which may be targeted by using CBD. Most people who have Parkinson’s disease exhibit symptoms like REM sleep behavior disorder and, in late-stage disease, signs of psychosis. CBD may be very beneficial in combating these symptoms and improving the quality of life for people who have Parkinson’s disease.

Signs of insufficient dopamine levels in your body include:

Other causes of dopamine deficiency are schizophrenia, stress, obesity, and even an unhealthy diet.

Weight Loss

Parkinson’s disease falls under the category of conditions referred to as Motor System Disorders. It is related to the central nervous system, affecting your movement. Since the condition affects balance and coordination, it leads to stiffness, shaking, and difficulties walking. Sadly, as the degenerative disorder progresses, it affects the neurons that process and produce dopamine; eventually, it kills them. Parkinson’s disease, therefore, causes dopamine deficiency by destroying your brain’s ability to produce and transmit dopamine.

Dopamine levels can affect your mental well-being in so many ways. Sadly, it is impossible to measure the levels of dopamine in your brains. However, you can develop this condition through any of the following mechanisms: if dopamine is broken down too quickly; if you have too few or damaged dopamine receptors; or if your body produces inadequate dopamine levels, or circulates the dopamine inadequately. Now that you’re familiar with dopamine deficiency, here’s a look at its potential causes.

By itself, dopamine deficiency is not a medical diagnosis. It is a hereditary condition and a genetic disorder that can be passed down through your genetics. Do you feel like you have no interest in life when you wake up every morning? You might be suffering from dopamine deficiency.

Here’s the really neat part: when you associate a particular activity with pleasure and happiness, just anticipating that activity is enough to raise dopamine levels in your body. It could be sex, food, shopping, or even watching a favorite TV show. That’s why dopamine is also called the ‘reward chemical’ because it’s involved in your body’s pleasure-reward system. It’s even referred to as the motivation molecule since it gives you the drive and the focus you need to increase productivity.