Someone with an autoimmune disease may consider cannabinoid therapies for their ability to decrease inflammation, modulate the immune system, and help to bring the system back into balance.
Malfait, et al. “The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis”. Proc Natl Acad Sci USA. 2000
Immune system modulation
There has been some preclinical investigation focusing on the role of particular cannabinoids in AI disease models. CBD has been found to modulate the immune system instead of suppressing it. Cannabidiol also slows down T-cell production and suppresses immune system memory, meaning that CBD could cut down on the likelihood of future autoimmune attacks. CBD has also been found to increase the expression of genes that deal with oxidative stress, which may reduce cell damage from autoimmune attacks. As for THC, this cannabinoid is immunosuppressive only at very high doses. In low doses can be helpful as an analgesic and anti-inflammatory. Its ability to activate CB2 receptors may down regulate T cell function and decrease the harmful effects of immune cells.
Additional approaches one can take to lower inflammation:
Cannabis is a unique biphasic botanical remedy that can bring the system back into balance in numerous regards. Based on current research, cannabis therapies may provide benefit for autoimmune disease in three basic ways: modulation of the immune system, decreasing general inflammation, and helping to assist the digestive system. Cannabis medicine may also treat symptoms of specific autoimmune diseases like ALS, rheumatoid arthritis, ulcerative colitis and Crohn’s, fibromyalgia, Huntington disease, multiple sclerosis, and others. The plant may decrease chronic pain, inflammation, and spasms associated with some of these conditions. There have been few specific investigations on cannabinoid treatment for AI, due to federal prohibition on human clinical trials. However, extensive studies in test-tubes and in animals have reported the anti-inflammatory benefits of cannabinoids for specific AI conditions like multiple sclerosis and rheumatoid arthritis.
Cannabinoid molecules, named endocannabinoids, form in the human body as well as all other vertebrates and owe their name to chemical structure similarities they share with cannabinoids in hemp. The endocannabinoids in our bodies function as intercellular lipid messengers that are released from one cell membrane, activating the receptors on the membrane of another cell. Their signals are retrograde because they move, or more accurately, exchange materials and communicate opposite to the usual direction of the intercellular signals. This behavior is what makes them an active substance, lowering the secretion of insulin in the bloodstream, reducing pain and temperature and calming the immune system.
2. Demuth DG, Molleman A. Cannabinoid signaling. Life Sci. 2006;78(6):549–563. doi: 10.1016/j.lfs.2005.05.055. [PubMed] [Cross Ref]
What is CBD oil?
Our body is capable of producing the message-transmitting cannabinoids on its own, however, when our body is sick, tired or under severe stress, the production stops and we no longer produce our own cannabinoids. In such cases, we can assist with an input of phytocannabinoids. These can be found in hemp, with CBD being the most researched one. Hemp cannabinoids bind to the same receptors as cannabinoids produced in our own bodies. This makes the body recognize and accept them as its own. Cannabinoid receptors are also found in skin cells, which enables CBD to function effectively and locally through the skin as well.
1. Zuardi AW, et al. Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug. Braz J Med Biol Res. 2006;39(4):421–429. doi: 10.1590/S0100-879X2006000400001. [PubMed] [Cross Ref]
Hemp is gaining popularity on a daily basis. This controversial plant, which many still associate with illegal substances, carries a veritable treasure trove of substances that have a soothing effect on a variety of problems. It is also becoming increasingly popular in the field of medicinal uses. Numerous clinical studies and scientific papers reported positive results in therapies involving cannabis resin. The best-known ingredient of cannabis resin is the CBD cannabinoid that proved effective in the field of various auto-immune disorders, Alzheimer’s and Parkinson’s disease. It also recorded positive effects with Crohn’s disease, insomnia, diabetes, depression, and several others. CBD oil is also effective in the field of skin problems, calming autoimmune reactions on the skin and reducing sebum secretion from the sebaceous glands.