[Source: Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science. Baron EP. Headache. 2018 Jul; 58(7):1139-1186. PMID: 30152161]
In manufacturing, Axon uses C02 extraction, which is one of the cleanest ways to extract CBD for human consumption. Once extracted, our CBD is maintained in pure hemp seed oil. It’s a fast-acting formula that is all-natural, with no flavors, colors, or THC.
CBD oil has been explored in the treatment of diabetes, depression, arthritis, and other ailments. The study also cites the fact that CBD is safe. It doesn’t alter heart rate, blood pressure, or body temperature, nor does it negatively affect psychomotor and psychological functions.
What’s the Correct Dosage for CBD Oil?
A lot of CBD brands include only small amounts of real CBD — as little as 3 mg. Since CBD has been proven safe even in high doses, there is really no reason not to increase your chances of results by using a stronger dose.
Hemp is a long-standing industrial product that people have grown for hundreds of years. As a matter of fact, 3rd President of the United States Thomas Jefferson grew hemp. It’s useful for making all kinds of products, such as clothing, rope, and food.
When it comes to CBD when combined with THC there are plenty of side effects. However, pure CBD oil is a different story. Pure CBD with 0.0% THC has surprisingly few side effects, which most of us would probably consider minor. The possible side effects include:
As more and more people try isolated CBD oil for migraine, we can begin to gather and publish the supporting data.
Endocannabinoid levels represent your overall health. Things that hurt the human body, such as migraine triggers, deplete the body’s natural endocannabinoids. Because your health and endocannabinoid levels are unique to you, the dosage of cannabinoids needed to boost endocannabinoids for migraine prevention is also unique to you. The CBD doses that work for others may not work for you and vice versa.
The things that trigger your migraines are unique to you, and CBD may reduce those triggers in different ways. For example, CBD used to control a migraine trigger like anxiety is different from CBD used to help reduce the symptoms of a migraine trigger like a neck injury. In the case of anxiety, CBD may help you eliminate the source of the migraine trigger, whereas in the case of a neck injury, CBD might relieve the pain and migraines that come from a neck injury without eliminating the neck injury itself.  Because CBD targets migraine triggers in different ways, the ideal dosage will depend on the types of triggers you have and the severity of those triggers.
14. Endocannabinoid Levels and Migraine Triggers
That being said, the ideal dosage of a full-spectrum hemp extract is likely to fall between 15 mg and 100 mg per day for migraine prevention and relief. There is a way to find a CBD dosage that may prevent your migraines, but there are some things you need to know about hemp first because there are many ways to screw this up.
Here’s the definition of the entourage effect from my book:
Most hemp manufacturers recommend starting off with a small dose, such as 5 mg per day, and increasing that dose by 5 mg every week until you feel best. Many migraine sufferers have an endocannabinoid deficiency and may want to try a larger dose, such as 15 mg or 25 mg, and if they feel great, they may want to increase that dose 5 mg every week until they find the desired dose. The dosage should be reduced if you feel any side effects.
Most of the treatments for migraines involve prophylactic and/or symptomatic support rather than addressing the underlying cause.
We’ve long known about the ability for cannabis to inhibit the release of serotonin from the platelets .
Migraines are a type of severe, recurring headache accompanied by at least one, or various, physical symptoms such as nausea, vomiting, and sensitivity to light or sound.
Most people who suffer migraines will use [their preventive medications and prescriptions. However, milder migraine sufferers may use] over the counter pain medications such as Excedrin, Tylenol, Ibuprofen, and Aspirin, however, this only help curb the intensity of mild episodes. They do little for actually clearing up a migraine and are rarely strong enough to completely alleviate symptoms. Most often they’re used in conjunction with routine prescription medication.
For example, the cannabis plant contains as many as 80 different cannabinoids and well over 100 different terpenes in its leaves and resin.