Objective: The aim of the present review was to describe the state of art about the pre-clinical research, the potential use and, when existing, the clinical evidence related to CBD in the neurological field.
Background: Cannabidiol (CBD) is among the major secondary metabolites of Cannabis devoid of the delta-9-tetra-hydrocannabinol psychoactive effects. It is a resorcinol-based compound with a broad spectrum of potential therapeutic properties, including neuroprotective effects in numerous pathological conditions. CBD neuroprotection is due to its antioxidant and antiinflammatory activities and the modulation of a large number of brain biological targets (receptors, channels) involved in the development and maintenance of neurodegenerative diseases.
Method: Collection of all the pre-clinical and clinical findings carried out investigating the effects of CBD alone, not in combination with other substances, in the neurological arena with the exclusion of studies on neuropsychiatric disorders.
Conclusion: Pre-clinical evidence largely shows that CBD can produce beneficial effects in AD, PD and MS patients, but its employment for these disorders needs further confirmation from well designed clinical studies. CBD pre-clinical demonstration of antiepileptic activity is supported by recent clinical studies in human epileptic subjects resistant to standard antiepileptic drugs showing its potential use in children and young adults affected by refractory epilepsy. Evidence for use of CBD in PD is still not supported by sufficient data whereas only a few studies including a small number of patients are available.
Results: Laboratory and clinical studies on the potential role of CBD in Parkinson’s disease (PD), Alzheimer’s disease (AD), multiple sclerosis (MS), Huntington’s disease (HD), amyotrophic lateral sclerosis ALS), cerebral ischemia, were examined.
Seizure treatment also claims the one hemp-derived drug that has FDA approval. The drug is called Epidiolex and can indeed help ease the suffering of seizure-prone people.
Even more intriguing, hemp-derived CBD also interacts with many non-cannabinoid receptor systems in the nervous system. These include dopamine receptors, which affect many aspects of behavior and cognition.
CBD directly interacts with your central nervous system. But how, exactly? While many people assume that the intoxication from THC is the only effect cannabis can have, the plant is much more complex than that. Hemp and marijuana are both types of cannabis, and both contain hundreds of compounds and chemicals. THC is what gets users “high”, but the hemp plant has less than 0.3% THC content and produces higher levels of CBD. This is part of the reason people are interested in CBD— they want potential benefits without the intoxication. Well, hemp provides exactly that.
– The Spinal Cord: The spinal cord is responsible for carrying signals between the brain and the rest of the body. It also coordinates motor function by transporting motor commands from the brain to the muscles. Sensory information also travels through the spinal cord.
CBD’s ability to target specific serotonin receptors, the serotonin 1A receptor, has remarkable possibilities. These receptors play a significant role in the release of cortisol and oxytocin, which are the hormones that cause reactions to stress, metabolism, and social behavior, respectively. CBD’s apparent ability to target serotonin 1A receptor means that it could impede certain problems such as schizophrenia, depression, anxiety, and neuropathic pain.
CB2 Receptors: These receptors are prominent in the immune system and peripheral nervous system. The spleen, thymus gland, and tonsils contain CB2 receptors.
One of the most publicized hemp effects on the nervous system is its effect on seizures. CBD use can reduce both the frequency and intensity of seizures for people with MS (Multiple Sclerosis), epilepsy, and other seizure-related disorders. A study published in the Journal of Epilepsy Research showed that CBD improved seizure control in people with epilepsy.
As the only THC is the element that shows up on a positive drug report, CBD is as harmless in drug tests as it is non-intoxicating.
And to top everything off, the final product is enhanced with terpenes, which are known to enhance the functionality of CBD oil substantially.
Moreover, in terms of variety, JOY organics offer four flavors and four very distinct strengths of CBD oil for you to choose whatever suits you the best freely. The various strengths of CBD are dependent on flavor as well.
The significance is so that 0.3 percent THC is the amount that cannot produce an intoxicating effect in humans. Even at this minimal level, THC still turns a marijuana test positive. But a CBD product is now legal for consumption if it contains less than 0.3 percent tetrahydrocannabinol in all the states of the US under federal law.
So, it is important to make sure that the manufacturing company uses an organically grown hemp plant to extract their CBD. Secondly, in the name of organic elements, due to the modernization and advancement of science, our generation has come up with alternative solutions to enhance certain qualities of plants by introducing genetically modified strains to the original strain of hemp plant.
The potency of this sample-sized bottle of CBD oil is just the same as its high-potency 2400 mg CBD oil as it delivers 80 mg CBD per dose. Just the total contents of the bottle have changed from 30 ml to 5 ml.
But what if, in a devastating scenario, some small part of this perfect sequence stops working? Imagine it would be like an orchestra without the first key violin or the Olympics with none of the water sports.