CBD also exerts an anti-cancer effect by activating PPAR s on the surface of the cell’s nucleus.
Scientists also refer to TRPV1 as a “vanilloid receptor,” named after the flavorful vanilla bean. Vanilla contains eugenol, an essential oil that has antiseptic and analgesic properties; it also helps to unclog blood vessels. Historically, the vanilla bean has been used as a folk cure for headaches.
Although CBD has little binding affinity for either of the two cannabinoid receptors ( CB1 and CB2 ), cannabidiol modulates several non-cannabinoid receptors and ion channels. CBD also acts through various receptor-independent pathways—for example, by delaying the “reuptake” of endogenous neurotransmitters (such as anandamide and adenosine) and by enhancing or inhibiting the binding action of certain G-protein coupled receptors.
PPAR s – nuclear receptors
CBD also functions as an allosteric receptor modulator, which means that it can either enhance or inhibit how a receptor transmits a signal by changing the shape of the receptor.
CBD binds to TRPV1 , which can influence pain perception.
CBDA [Cannabidiolic acid], the raw, unheated version of CBD that is present in the cannabis plant, also has a strong affinity for the 5- HT1A receptor (even more so than CBD ). Preclinical studies indicate that CBDA is a potent anti-emetic, stronger than either CBD or THC , which also have anti-nausea properties.
PPAR receptors also regulate genes that are involved in energy homeostasis, lipid uptake, insulin sensitivity, and other metabolic functions. Diabetics, accordingly, may benefit from a CBD -rich treatment regimen.
CBD, on the other hand, has a low binding affinity for CB1 and CB2 receptors. Instead, CBD interacts with the way these receptors bind with THC, modulating the psychoactive effects. Beyond the endocannabinoid receptors, CBD activates other receptors and ion channels that have a plethora of positive effects. For instance, CBD can activate the 5-HT1A serotonin receptor that helps alleviate symptoms such as anxiety, nausea, vomiting, and the perception of pain.
While THC alleviates pain symptoms by binding to cannabinoid receptors, CBD mediates pain perception by altering the way THC binds to those receptors. CBD also binds to the receptors that are responsible for regulating many important functions involved in homeostasis, equilibrium among interconnected systems of the body. As a result, some of the major benefits from taking CBD apart from pain relief include neuroprotective effects like reducing inflammation, convulsions, anxiety, and nausea. CBD can even assist with falling asleep and blood sugar regulation.
How Does THC Work?
Many people who use CBD to treat their ailments find that CBD by itself is enough to experience relief. Taking CBD with THC often confers the effects of both with greater efficiency. Commonly referred to as the “entourage effect”, the addition of different cannabinoids tends to increase the pain relieving and palliative effects. CBD has also been reported to negate the overly intense psychoactive effects of high doses of THC. Although THC and CBD can both be effective on their own, many patients benefit from finding the right balance of the two cannabinoids.
Everyone has an endocannabinoid system that utilizes receptors (CB1 and CB2) throughout the body to regulate signals from and to our brains. These receptors are activated with endocannabinoids produced by the body but are also activated by cannabinoids found in marijuana. THC has a particular affinity for binding with CB1 receptors, which helps in the relief of pain, nausea, insomnia, and can aid in appetite stimulation. This is also responsible for the psychoactive or “high” effects that are associated with cannabis.
Chances are, you’ve heard of THC. This cannabinoid produced by marijuana has pain relieving and palliative effects, but it is most famous for its psychoactive properties. There are also multiple cannabinoids found in marijuana that affect the body differently than THC. Cannabidiol or CBD has many of the same benefits that THC has; however, it does not produce the hallucinogenic or “high” effects. Different amounts of THC and CBD can be used on their own or in combination to create a unique medicinal effect that can address a wide array of issues.