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cbd oil stomach cancer

What is CBD oil, and how does it differ from marijuana and hemp?

CBD oil (cannabidiol) is everywhere these days. Once available only at novelty or vitamin shops, it’s now also at your local grocery store, pharmacy or even yoga studio.

Studies on a certain CBD manufacturer showed its products were contaminated with a chemical known as 5F-ADB, which mimics THC. 5F-ADB is classified by the U.S. Drug Enforcement Administration as illegal, potentially addictive and with no accepted medical use.

Marijuana and hemp are both varieties of the cannabis sativa plant. Both contain cannabidiol (CBD) and tetrahydrocannabinol (THC) — the two most-common, known active ingredients.

There’s still a lot to learn. So always let your health care team know if you are using CBD oil. That way, we can make sure nothing interacts adversely with your cancer treatments or other medications.

U.S. estimates for the year 2017 by the American Cancer Society are:

You can affix transdermal patches laced with medical cannabis to your skin. They’re similar to nicotine patches, but use medical marijuana instead.

According to National Cancer Institute (NCI) estimates, in 2017, there’ll be around 28,000 new gastric cancer cases. NCI also reports 1.7 percent of new cancer cases in the U.S. are stomach cancer.

Prevention

Gastric cancer treatments like radiation therapy and chemotherapy may lead to long-term effects like:

The cause of gastric cancer isn’t clear, and therefore, it’s difficult to know how to prevent it. However, there are steps you can take to help reduce your risk of stomach cancer. These measures include making small, everyday changes to your life, including:

You can also use cannabis topically. It’s an easy way to get your marijuana and gastric cancer treatment without having to consume it orally. Physicians often suggest this method for children and older people who are not comfortable with consuming marijuana orally.

The best marijuana and gastric cancer strains have multiple cancer symptom-fighting properties. Therefore, if you or someone you love is battling cancer and its debilitating symptoms, below is a list of strains specific to target the symptoms you may be experiencing.

Qin, S. et al. XIAP inhibits mature Smac-induced apoptosis by degrading it through ubiquitination in NSCLC. Int J. Oncol. 49, 1289–1296 (2016).

In conclusion, our study showed that CBD induces apoptotic cell death in gastric cancer cells, which is triggered by ER stress generation and subsequent XIAP inhibition by Smac (Fig. 7). Taken together, our results suggest the potential of CBD in novel treatments against gastric cancer.

Department of Medicine, Meharry Medical Center, Nashville, Tennessee, 37208, USA

Immunoblotting

Usually, XIAP has higher expression in cancer tissues than in normal tissues, whereas Smac has lower expression in cancer tissues than in normal tissues, both of which are associated with poor prognosis and survival rate of patients. Moreover, it has been reported that XIAP and Smac are negatively correlated in various cancers such as renal cell carcinoma and non-small cell lung cancer 16,17,18 . However, the underlying mechanism is still not thoroughly understood.

Department of Surgery, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea

For overexpression of target genes, myc-XIAP plasmid and pSmac-green fluorescent protein (GFP) was obtained from Addgene. myc-XIAP plasmid and pSmac-GFP were incubated on cells with Lipofectamine 2000 (Invitrogen). After 6 h of incubation at 37 °C, expression media were replaced with fresh cultured medium.

AGS cells were seeded at a density of 3 × 10 4 cells per well in XF24 cell culture microplates (V7-PS; Seahorse Bioscience, North Billerica, MA, USA) and treated with 4 μM CBD. Cell culture medium was replaced with XF24 medium containing glucose 1 h before measurement. OCR was measured using an XF24 extracellular flux analyzer. The obtained OCR was validated by adding oligomycin (2 μg/ml), carbonyl cyanide m-chlorophenyl hydrazine (CCCP, 5 μM), and rotenone (2 μM) sequentially.