Similarly, it’s an insufficiently investigated supplement with a relatively unknown safety profile. The list of side effects listed in this article is, therefore, not a definite one.
And since tinctures and sprays are directly applied in the mouth, they will quickly reach the salivary glands and cause dry mouth. Mouth sprays may also cause a stinging sensation and even burns, especially if they contain alcohol [9, 78].
2) Digestive Issues
In contrast, very high doses may even trigger anxiety and irritability. This was the case in 7-9% of the children in 2 clinical trials using CBD for seizures and autism [40, 41].
The downside of blocking the immune response is that it may make people with weakened immune systems more prone to infections. Thus, people on immunosuppressants or with conditions such as HIV, diabetes, and Down syndrome might want to avoid it .
Plus, CBD itself is broken down by CYP enzymes, especially by CYP34A and CYP2C19. Drugs that block these enzymes (such as ketoconazole and ritonavir) will enhance its effects, while those that activate them (such as phenobarbital and rifampicin) will have the opposite effect [75, 4].
CBD oil comes as full-spectrum oils or in forms that contain CBD isolates. Unlike isolates, which contain CBD only, full-spectrum oils contain a variety of compounds found naturally in the cannabis plant, including proteins, flavonoids, terpenes, and chlorophyll. Alternative practitioners believe these compounds offer more substantial health benefits, although there is no clear evidence of this.
Outside of these two disorders, CBD’s effectiveness in treating seizures is uncertain. Even with Epidiolex, it is uncertain whether the anti-seizure effects can be attributed to CBD or some other factor.
CBD oil can interact with certain medications, including some drugs used to treat epilepsy. CBD inhibits an enzyme called cytochrome P450 (CYP450), which metabolizes certain drugs. By interfering with CYP450, CBD may either increase the toxicity or decrease the effectiveness of these drugs.
What to Look For
There is currently no known “correct” dose of CBD oil. Depending on individual needs and what is being treated, the daily dose may range between 5 and 25 mg.
Clinical research has shown that CBD oil can trigger side effects. Severity and type can vary from one person to the next.
Since some CBD oils contain trace amounts of THC, you should avoid driving or using heavy machinery when taking CBD oil, particularly when first starting treatment or using a new brand.
Proponents claim that CBD oil can treat a wide variety of health problems, including:
There are many other medicines that should not be taken with CBD. Doing so may increase the effects of those medicines. As an example, taking CBD with medicines that cause drowsiness may cause the person to be even more sleepy.
A review of clinical trials of the effect of cannabinoids on sleep suggested that cannabinoids could improve sleep quality, decrease sleep disturbances, and decrease the time it takes to fall asleep. However there were many limiting factors such as a small number of people studied and they evaluated sleep within studies of other illnesses.
CAUTION: CBD should not be used with medicines that are prescribed to control seizures.
CBD and Medical Conditions
The dosing of CBD for different conditions is still being studied.
Other oral forms of CBD are edible gummies and capsules. Topical CBD may also be a lotion, cream, or balm.
Topical cannabidiol oil was studied in 29 people with lower limb peripheral neuropathy. After using the oil for 4 weeks, the people had less intense and sharp pain and fewer other uncomfortable sensations.
CBD, or cannabidiol, is recommended for everything from anxiety to indigestion. And, people are also using it for a wide variety of reasons.