This page is regularly updated, to include the most recently available clinical trial evidence.
In small amounts, probably not for most people. In large amounts over time . well, read on to get a gist of the risks.
Like THC, CBD is a compound in cannabis. Unlike THC, CBD won’t get you “high”, but is has shown promise in animal research for the treatment of anxiety, pain, inflammation, cancer, and more. Unfortunately, as of 2021, human trials are still few.
Two reasons. First, isolated CBD won’t get you “high”, unlike THC (the other main cannabinoid in cannabis). Second, isolated CBD has shown a ton of promise in animal research for the treatment of (anxiety, pain, inflammation, cancer, etc). Unfortunately, as of as of 2019, there are relatively few human trials. And unregulated CBD often contains way lower or higher doses than the label states, sometimes even containing unlisted THC. Things are heating up though: in 2018, the FDA approved the first CBD pharmaceutical (Epidiolex ® ) for two rare types of epilepsy. Stay tuned to this page, as nearly 190 trials are underway!
The main studied benefit to CBD is on two rare forms of epilepsy (Lennox-Gastaut and Dravet syndrome),  but potential benefits stretch from common maladies (anxiety,  chronic pain  ) to reduction in inflammation  , even to potential benefits for cancer.  Human randomized trials are quite scarce, though.
Anywho, back to CBD’s main effects. It appears to impact a variety of other receptors in the body, including an important receptor involved in pain and stress response, called TRPV1.    Other receptors that CBD impacts include GPR55, 5HTI-alpha, and adenosine A2A, which variously can help with inflammation, pain, anxiety, and even potentially cancer.    
Cannabidiol (CBD) has been recently covered in the media, and you may have even seen it as an add-in booster to your post-workout smoothie or morning coffee. What exactly is CBD? Why is it suddenly so popular?
Side effects of CBD include nausea, fatigue and irritability. CBD can increase the level in your blood of the blood thinner coumadin, and it can raise levels of certain other medications in your blood by the exact same mechanism that grapefruit juice does. A significant safety concern with CBD is that it is primarily marketed and sold as a supplement, not a medication. Currently, the FDA does not regulate the safety and purity of dietary supplements. So, you cannot know for sure that the product you buy has active ingredients at the dose listed on the label. In addition, the product may contain other (unknown) elements. We also don’t know the most effective therapeutic dose of CBD for any particular medical condition.
How is cannabidiol different from marijuana?
CBD has been touted for a wide variety of health issues, but the strongest scientific evidence is for its effectiveness in treating some of the cruelest childhood epilepsy syndromes, such as Dravet syndrome and Lennox-Gastaut syndrome (LGS), which typically don’t respond to antiseizure medications. In numerous studies, CBD was able to reduce the number of seizures, and, in some cases, it was able to stop them altogether. Videos of the effects of CBD on these children and their seizures are readily available on the Internet for viewing, and they are quite striking. Recently the FDA approved the first ever cannabis-derived medicine for these conditions, Epidiolex, which contains CBD.
CBD may offer an option for treating different types of chronic pain. A study from the European Journal of Pain showed, using an animal model, CBD applied on the skin could help lower pain and inflammation due to arthritis. Another study demonstrated the mechanism by which CBD inhibits inflammatory and neuropathic pain, two of the most difficult types of chronic pain to treat. More study in humans is needed in this area to substantiate the claims of CBD proponents about pain control.
Image: yavdat/Getty Images
Cannabidiol, or CBD for short, is the main non-psychoactive compound within the Cannabis sativa plant. This 100% natural, safe and legal ingredient has been the subject of much attention recently and is now available to our customers in a variety of forms.
We source our CBD from EU-certified hemp that has been cultivated without the use of any harmful chemicals or pesticides. To further ensure quality, our CBD is extracted using the gold standard CO2 method which results in a highly pure end product free from psychoactive elements or contaminants. As a result, our full range contains zero THC.
Lastly, Simply Supplements is proud to be a member of the Cannabis Trades Association, ensuring you receive the highest quality product every time.