Although CBD is generally well tolerated, THC may decrease potential side effects of CBD. THC may also play an important role in CBD’s pain-relieving effects, by aiding its influence on the endocannabinoid system.
Importantly, CBD is hydrophobic and lipophilic, meaning it will dissolve in fats. The dissolution helps it to be carried across the blood-brain barrier and affect your CNS, where it can have a broad range of positive effects on pain including:
Get to Know the CBD Isolate, Broad, and Full Spectrum Products
The 2018 US Farm Bill legalized the growing of hemp and sale of hemp-derived products, which made CBD legal at the federal level (mostly). As noted, hemp is a species of the marijuana plant with one very important distinction: the variety must have less than 0.3% THC. So, if the CBD you buy comes from a hemp plant with less than 0.3% CBD and is grown in accordance with the 2018 Farm Bill regulations, and you live in a state where CBD is legal, you are in full abidance of the law.
1. Corroon J, Phillips JA. A cross-sectional study of cannabidiol users. Cannabis Cannabinoid Res. 2018;3(1):152-161.
Clear? You likely still have questions. Read on for specific products and which symptoms they aid.
However, it should be noted that the studies used a variety of cannabis-based medicines (e.g., inhaled cannabis, sprays, and oral tablets containing THC and/or CBD from plant sources or made synthetically), some of which are more likely to result in these side effects than products without THC.
While many companies now sell CBD oil online and in dispensaries, use of the oil isn’t legal in every state. Because state laws vary greatly when it comes to cannabis products, it’s crucial to confirm that use of CBD oil is legal in your state.
The research on the side effects of CBD oil is extremely limited. CBD is the major non-psychoactive component of cannabis. Due to the lack of regulation, there is inconsistency in content and purity. The amount of CBD may not be consistent, and products can contain varying amounts of the psychoactive component THC.
Side Effects and Safety
A type of pain triggered by damage to the somatosensory system (i.e., the system responsible for processing sensory stimuli), neuropathic pain often occurs in people with conditions like diabetes and multiple sclerosis.
In studies using varied doses, routes of administration, and combination or whole products with THC, a number of side effects have been reported. These include anxiety, changes in appetite and mood, diarrhea, dizziness, drowsiness, dry mouth, low blood pressure, mental confusion, nausea, and vomiting.
In a report published in Pediatric Dermatology in 2018, scientists reported three cases of topical CBD (applied as an oil, cream, and spray) use in children with a rare, blistering skin condition known as epidermolysis bullosa.
Lana Butner, ND, LAc, is a board-certified naturopathic doctor and licensed acupuncturist in New York City.
They also provided guidance for the Arthritis Foundation, who recently surveyed 2,600 people with arthritis and found that 29% currently use CBD to treat arthritis symptoms.
Route of administration matters. CBD is best taken in pill or capsule form for slow extended release or as an oral tincture (infused oil that contains CBD) for faster effect onset.
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Want to learn more on this topic? Listen to this podcast from the Rogel Cancer Center on Medical Marijuana for Cancer Patients.
So many people are turning to CBD as an alternative pain reliever, especially in light of the opioid crisis, that in a commentary published in Annals of Internal Medicine, Boehnke and Daniel Clauw, M.D., director of the Chronic Pain and Fatigue Research Center, provided advice for clinicians on how to counsel their patients about CBD and cannabis use.
Boehnke and Clauw recommend that people with chronic pain talk to their doctor about adding CBD to their treatment plan, and continue to use their prescribed medication. They offer the following advice for people wanting to try CBD:
Much of the research literature around CBD in particular supports its use as a treatment for childhood epilepsy. Indeed, in 2018 the FDA approved the CBD-based drug Epidiolex as a drug for childhood epileptic conditions. In a substantial policy shift, Epidiolex was designated as Schedule V, which is the least restrictive drug schedule and indicates little potential for abuse.
People looking for a safer pain reliever are turning to cannabis-derived CBD. Michigan Medicine experts weigh in on what’s currently known about the trendy supplement.