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does cbd work

Tell me all I need to know about using cannabidiol for chronic pain.

Oral ingestions come in many forms such as:

SO, WHAT IS CBD EXACTLY?

That depends on how you take your CBD oil. The most predictable consumption method is sublingual (under the tongue) using a spray or tincture. According to the American Arthritis Foundation, 16 effects are usually felt within 15 to 45 minutes.

These days, it seems like you can purchase CBD just about anywhere, but if it’s an option, you may want to visit a medical marijuana dispensary. Buying CDB from a medical dispensary doesn’t guarantee the product’s quality but it’s a good place to start. Before you go:

2. Rudroff T, Sosnoff J. Cannabidiol to improve mobility in people with multiple sclerosis. Front Neurol. 2018;9:183.

In 2018 Stephen Silberstein, director of the Headache Center at Jefferson University Hospital in Philadelphia, told the American Headache Society there were no studies of cannabis or CBD as migraine treatments, and none were underway.

Evelyn Nussenbaum, the mother of the first patient to receive Epidiolex, remembered reading a study about treating seizures with CBD in (you guessed it) rats in 2011, and thinking, “My son needs access to that.” Her son Sam became part of a one-person trial at the University of California-San Francisco. His seizures were drastically reduced without side effects, and in 2015, the doctor overseeing his care co-authored a study of 214 patients with severe childhood-onset epilepsy that showed a 36.5% median decrease in seizures over a 12-week treatment period with oral CBD.

It stands to reason that the aforementioned possible reductions of stress, anxiety, and pain, combined with improved sleep, might help a person to unwind. Ditto for easing many menstrual symptoms.

Could CBD help me chill out?

Are you a rat or a mouse? If so, chances are good that CBD administered in moderate doses—10 mg/kg is too low; 100 mg/kg is too high—could have an anti-anxiety effect, particularly if you’re feeling anxious because you’ve been placed in a maze or are panicking because a snake has been introduced to your environment.

On top of that, researchers hypothesize that the endocannabinoid system—the network of neurotransmitters in our brains and nervous systems that’s stimulated by cannabinoids, including CBD—acts as a powerful “dimmer switch” that helps modulate brain activity and mood. Some even suggest it’s the endocannabinoid system, rather than endorphins, that exercise activates, resulting in the euphoric elation of a “runner’s high.”

For humans, the research is thinner. A couple of studies have shown CBD to have an anti-anxiety effect in very specific situations. In one of those, researchers gave 60 people either a placebo, the anti-anxiety drug clonazepam (sold under the brand name Klonopin), or one of three doses of CBD (100 mg, 300 mg, or 900 mg) before a public speaking test. Those who took the medium dose (300 mg) of CBD showed lower anxiety than those who took the lowest and highest doses of CBD, or the placebo. (The clonazepam worked well, too, though it also generated a more sedative effect than the medium-dose CBD.)

But as for CBD alone, I am so sorry to tell you we are back to the critters. Rats, you may be relieved to learn, are incapable of vomiting. But Asian musk shrews can, and a relatively low dose of CBD (5 mg/kg) was shown to suppress the reflex. It also kept rats—who can’t seem to get a break—from retching.

Recently, the F.D.A. sent a warning letter to Curaleaf Inc. about its “unsubstantiated claims” that the plant extract treats a variety of conditions from pet anxiety and depression to cancer and opioid withdrawal. (In a statement, the company said that some of the products in question had been discontinued and that it was working with the F.D.A.)

For students with generalized social anxiety, a four-minute talk, with minimal time to prepare, can be debilitating. Yet a small experiment in the journal Neuropsychopharmacology found that CBD seemed to reduce nervousness and cognitive impairment in patients with social anxiety in a simulated public speaking task.

Cannabidiol, or CBD, is the lesser-known child of the cannabis sativa plant; its more famous sibling, tetrahydrocannabinol, or THC, is the active ingredient in pot that catapults users’ “high.” With roots in Central Asia, the plant is believed to have been first used medicinally — or for rituals — around 750 B.C., though there are other estimates too.

Does CBD help sleep and depression?

By Dawn MacKeen

Dr. Smita Das, chair of the American Psychiatric Association’s Council on Addiction Psychiatry’s cannabis work group, does not recommend CBD for anxiety, PTSD, sleep or depression. With patients turning to these to unproven products, she is worried that they may delay seeking appropriate mental health care: “I’m dually concerned with how exposure to CBD products can lead somebody into continuing to cannabis products.”

Just as hemp seedlings are sprouting up across the United States, so is the marketing. From oils and nasal sprays to lollipops and suppositories, it seems no place is too sacred for CBD. “It’s the monster that has taken over the room,” Dr. Brad Ingram, an associate professor of pediatrics at the University of Mississippi Medical Center, said about all the wild uses for CBD now. He is leading a clinical trial into administering CBD to children and teenagers with drug-resistant epilepsy.

More than 60 percent of CBD users were taking it for anxiety, according to a survey of 5,000 people. Does it help?