How much CBD should I take for epilepsy and seizures?
What is the best CBD oil for epilepsy and seizures?
How does CBD work to effect epilepsy and seizures?
What are the side effects of CBD?
6. Devinsky O, Marsh E, Friedman D, et al. Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial. The Lancet Neurology. 2016;15(3):270-278.
In this FAQ, we will answer the above questions, and walk you through the basics of using Green Flower Botanical’s CBD products.
Start Low and Go Slow: The first step to finding your minimum effective dose is to establish a baseline dosage. Since many people report good results with CBD at low doses, we suggest you start with a minimal dose and slowly increase the dosage until you find results. Start with a small baseline dosage between 2-5mg, 2X or 3x daily (6-10mg total).
The anti-convulsant effects of CBD are not confined to these rare forms of epilepsy, however. Generally speaking, cannabinoids are anticonvulsant and have been referred to as “circuit breakers” because of their ability to reduce seizures and corresponding neurodegeneration. 2,3 ( https://www.ncbi.nlm.nih.gov/pubmed/18776886 , https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189640 /)
4. Press CA, Knupp KG, Chapman KE. Parental reporting of response to oral cannabis extracts for treatment of refractory epilepsy. Epilepsy & behavior : E&B. 2015;45:49-52.
etravirine will decrease the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Consider an increase in cannabidiol dosage (based on clinical response and tolerability) when coadministered with a strong CYP3A4 inducer.
cannabidiol will increase the level or effect of voriconazole by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Monitor Closely. Consider reducing the dose of sensitive CYP2C19 substrates, as clinically appropriate, when coadministered with cannabidiol.
cannabidiol will increase the level or effect of fosphenytoin by decreasing metabolism. Modify Therapy/Monitor Closely. Cannabidiol may potentially inhibit CYP2C9 activity. Consider reducing the dose when concomitantly using CYP2C9 substrates.
Monitor Closely (1) atazanavir will increase the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Consider reducing the cannabidiol dose when coadministered with a strong CYP3A4 inhibitor.
cannabidiol will increase the level or effect of lesinurad by decreasing metabolism. Modify Therapy/Monitor Closely. Cannabidiol may potentially inhibit CYP2C9 activity. Consider reducing the dose when concomitantly using CYP2C9 substrates.
CBD is perhaps one of the most exciting new treatment options for epilepsy — including epileptic syndromes such as Dravet syndrome that are problematically resistant to treatment.
There are many different forms of epilepsy and numerous potential causes for each one. It can, therefore, be difficult for doctors to pinpoint the exact cause of the seizures in many cases.
Motor onset conditions used to be referred to as “grand mal” seizures — in some circles, they still are. They result in full-body seizures and an inability to control the body while the seizures are occurring. They can last anywhere from a few seconds to a few hours. CBD is useful for these types of seizures due to its ability to relax muscle contractions around the body.
4. CBD Vape Oils & E-Liquids For Epilepsy
A pharmaceutical CBD preparation — Epidolex (cannabidiol) — was approved in 2018 for the treatment of Lennox-Gastaut syndrome (LGS) and Dravet syndrome — two forms of epilepsy known for resisting treatment.
Everybody responds to CBD differently. Some people require high doses; others much lower. You won’t know for sure the ideal dose you need without experience.
Roughly 40% of the people in this study had the frequency of seizures cut in half, and a quarter had an incredible 70% drop in episodes.
Focal onset epileptics experience abnormal electrical activity in only specific regions of the brain. They used to be called “partial seizures.”