Research shows that CBD acts on the enzyme FAAH, which breaks down anandamide. CBD actually slows down the enzyme’s activity, which leads to increased levels of anandamide in the body. 1 The reason why this is significant is because anandamide interacts with CB1 and CB2 receptors. Higher levels of anandamide would result in increased feelings of euphoria due to increased activation of CB1 receptors, as well as soothing of the tissues due to activation of CB2.
To summarize, there are many ways to modulate the body's cannabinoid system. Products containing CBD, THC, and BCP all affect the endocannabinoid system. We acknowledge that health care professionals may recommend different products containing different kinds of cannabinoid compounds for different health issues. However, at doTERRA we believe that BCP-containing products are the most effective for healthy individuals seeking a product that they can use for self-care.
CBD, by increasing levels of anandamide, has similar pharmacological effects as THC in that it affects the same two cannabinoid receptors, however the magnitude of the effect is much smaller compared with THC. CBD is generally considered non-hallucinogenic.
The endocannabinoid (EC) system helps the body manage anxiety, inflammation, and other physiological responses to different forms of stress. During strenuous exercise, stress, and other related stimuli, the body produces compounds called endocannabinoids. Endocannabinoids (ECs) are signaling molecules that trigger the activation of the EC system when they are detected by cannabinoid receptors.
A “runner’s high” is a perfect example of the EC system at work. After a long period of strenuous exercise, the body begins to produce anandamide in order to activate CRs and turn on the EC system. The “runner’s high” has two components: slight euphoria, and soothing of the discomfort in the muscles and joints. These two outcomes are linked with two distinct structures: the CB1 and CB2 receptors. CB1 receptors are mainly found in the brain and central nervous system, and are linked with pleasure and reward pathways. CB1 receptor activation leads to feelings of euphoria. CB2 receptors are found in the rest of the body, like the muscles, skin, and vital organs. They are mainly found on the surface of white blood cells, and their activation affects the regulation of inflammation chemicals called cytokines.
There is ample evidence pointing to the benefits of oral supplementation of beta-caryophyllene, but like CBD and hemp oil, further research in the form of human clinical trials is required. More promising are the low doses at which some of these studies have been conducted. These dosages suggest that as little as 1-2 drops of Copaiba oil or 3-4 drops of Black Pepper oil may provide noticeable results in humans. At this time, the systemic soothing properties of beta-caryophyllene have potential benefit as treatment for a wide range of health issues.* Still unexplored are the effects of CB2 receptor activation on human diseases for which there are few experimental models—such as learning disabilities and autism spectrum disorders—that many claim can benefit from using cannabis.
There are three distinct classes of cannabinoids: endocannabinoids, phytocannabinoids, and synthetic cannabinoids. Synthetic cannabinoids are found in certain pharmaceutical products designed to help with glaucoma, appetite stimulation, antiemetics, and other disease-linked targets. Endocannabinoids, on the other hand, are produced naturally by the body. These molecules are mainly composed of amines and amides. Endocannabinoids are pharmacologically similar to some phytocannabinoids, but vary greatly in their chemical structure. This gives different endocannabinoids the ability to produce different neurological responses, even when administered in similar doses. The primary function of endocannabinoids is to modulate normal physiological functions.
In summary, this article is not intended to be a complete picture of the benefits of beta-caryophyllene nor an outline of the properties of the endocannabinoid system. Rather, it is a statement of scientifically-accepted facts aimed to clear up the misleading information on the molecules in question. My hopes are that reading this article will help individuals in their personal research on cannabinoids and, most importantly, their decisions about which oils to use in their daily life.
The last class of cannabinoids is known as the phytocannabinoids. These are molecules that are produced by plants such as Cannabis and Copaifera. The Cannabis species produces the commonly known molecules THC and CBD, while the Copaifera plant family produces only BCP. Although BCP differs significantly from other cannabinoids in its structure, it nonetheless reacts selectively with the CB2 receptor, thus defining it as a cannabinoid. 2 However, it is chemically distinct from other cannabinoids, which is why it cannot cause a positive result on a drug test. BCP is classified as a sesquiterpene based on its chemical structure and makeup. Research on BCP is ongoing and will continue to add to our understanding of its potential value.
I’ve prepared this article in hopes that I can set the facts straight. Having worked as a medicinal chemist for 15 years, I’ve learned a great deal about the chemical properties of all kinds of essential oils. I’ve even conducted my own chemical analyses of hemp, CBD, and cannabis oil in my lab at doTERRA. In this article, I will discuss the chemical properties of cannabinoid compounds found in the various cannabis oils and compare them with beta-caryophyllene. Beta-caryophyllene is the main compound found in Copaiba, doTERRA’s alternative to cannabis.
Cannabidiol (CBD) oil can contain the psychoactive tetrahydrocannabinol (THC)
There is a wealth of information available in the scientific literature regarding the classes of cannabinoid compounds and the receptors involved in the endocannabinoid system. For several years now, beta-caryophyllene has been known to be a cannabinoid. But don’t just take my word for it. Back in 2008, a study by J. Gertsch et al. rolled off the press with the unambiguous headline, “Beta-caryophyllene is a dietary cannabinoid.” 1 The study was published in Proceedings of the National Academy of Sciences of the United States of America, a prestigious scientific journal. Since then, at least a dozen more papers have been published on the subject, reemphasizing the fact that beta-caryophyllene is a cannabinoid. 2-13
To be legally marketable, CBD oil is not supposed to contain any discernable amount of THC. 14 However, our own internal investigation involving analytical testing and evaluation has found that various CBD oils on the market do contain significant levels of THC and therefore could very likely trigger a psychoactive response and/or positive drug test. Our evaluation has also shown that commonly purchased brands of CBD oil can vary greatly in their claimed CBD content. In fact, in some samples we were not able to identify the presence of any CBD at all. In contrast, my analyses have shown that doTERRA oils are 100% free of THC, and oil compositions are consistent between batches.
The Copaiba is a large towering tree that grows in tropical rainforests of South America. For hundreds of years, traditional healers in northern Brazil have used copaiba trees for their health benefits. Copaiba oil is steam distilled from the resin of the tree.
Copaiba oil supports the health of the cardiovascular, nervous, digestive, immune, and respiratory systems.*
Copaiba Essential Oil Usage Tips:
Copaiba oil also has a plethora of benefits when taken internally. The main constituent of Copaiba oil is Beta-caryophyllene, which is also present in Black Pepper essential oil and helps soothe anxious feelings.* In addition to its emotional benefits, Beta-caryophyllene promotes healthy nervous, cardiovascular, and immune system function.* The oil also contains powerful antioxidants that boost immune health.* Copaiba oil is a well-loved oil because it relieves discomfort and promotes overall health, supporting people to feel and live their best.
Due to its beautifying effect on the skin, Copaiba oil is widely used in cosmetics. To promote a clear, smooth complexion, Copaiba oil may be combined with Cedarwood and diluted with Fractionated Coconut Oil and applied topically.
Powerfully relaxing, Copaiba oil comes from a fragrant tropical tree native to South America. Copaiba oil can help soothe anxious feelings and supports the cardiovascular, nervous, digestive, immune, and respiratory systems.*