Bottom line: Whether you’re ingesting CBD oil or CBD-infused edibles, it ultimately goes through the same lengthy digestive process, reducing the total CBD concentration in the bloodstream. With ingestion, it could take anywhere from one to two hours before the effects of CBD finally set in. From there, you may feel the effects for one hour to several hours, depending on the dose and your response to CBD.
Consuming CBD products sublingually leads to higher bioavailability compared to consuming CBD products orally. Photo by: Gina Coleman/Weedmaps
We have some insight into how long CBD remains in the blood, but there is little research on how long CBD is detectable in urine. In a 2016 study published in the Journal of Pain, participants were given different types of CBD-rich cannabis products, including oils, capsules, and flower. Two hours after administration, urine samples from all 15 subjects tested positive for CBD. The researchers followed one participant after the last day of administration and found that CBD was no longer detectable in the urine after 24 hours.
A 1991 study published in Pharmacology Biochemistry & Behavior examined the concentration of CBD in the blood after high doses daily. Over a six-week period, the research team administered a daily dose of 700 milligrams of CBD to 14 Huntington’s disease patients. One week after the dosing ceased, the CBD remaining in the blood was just 1.5 nanograms per milliliter and was “virtually undetectable” thereafter.
A 2018 review of existing CBD studies found that the estimated half-life of CBD was two to five days for those who took a daily oral dose. Other delivery methods delivered varied half-lives.
Here, we’ll cover the existing research on CBD and its interaction with the human body as well as what factors can affect how long CBD stays in your system.
While the time that CBD is detectable in the body will vary, we can deduce that CBD will likely leave the system after a week or two. Photo by: Gina Coleman/Weedmaps
Studies show that when CBD compounds are metabolized by the liver, it undergoes what is called the “first pass effect,” where enzymes in the liver reduce CBD concentration before the remainder is finally sent to the bloodstream and circulated throughout the body.
It depends on how you consume it. For the quickest potential anxiety relief, smoke high-CBD hemp flower, vape a CBD oil vape, or administer CBD sublingually, taking care to rub it in.
Bottom line: The relationship between CBD and the human body is complicated. The method of consumption, the quality of the CBD product, and individual body chemistry all determine how this cannabinoid moves through your body and how long it takes to leave your system.
Settling on the ideal CBD dosage is an important part of the treatment process, and will also impact how long CBD stays in your system. Hemp-derived CBD products are not intended to give the user a stoned buzz or intoxicated feeling, so there’s no need to be conservative with the dosage amount. Still, it’s recommended to start with a lower dosage and gradually increase it until the ideal effects are discovered.
That depends on the person, the quality of the CBD oil, and the consumption method. If you’ve used a CBD product in the past and it did nothing, check whether it came from a licensed brand or retailer that performs third-party lab tests. If this is the case, the dosage might be at play. Unlike THC and most other cannabis products, CBD is non-intoxicating and you can experiment with large increases in your dose with little risk. If you take any prescription medication, be sure to check with your doctor or pharmacist before trying CBD in any form.