Avoid using CBD oil with pain relievers like morphine. You also want to avoid using CBD oil with benzodiazepines. Since it may cause extreme drowsiness, discuss the risks of CBD drug interactions when you take a depressant medication.
Since your liver breaks down the medication, the CBD oil may enhance the effects of the medication. This is one of the rare negative side effects of CBD. Depending on the medication, it may lead to a bleeding risk or other health risks due to the changes to your medication. You want to pay particular attention to non-steroidal anti-inflammatory medications, or NSAIDs, because the medication and the CBD oil have a similar impact on your body. CBD drug interactions with NSAID medications relate to the impact of the medication. Hemp oil and NSAIDs both focus on reducing inflammation in the body.
Hemp-derived CBD oil is safe for most users, largely because CBD leaves your system fairly quickly, and the negative side effects of CBD are relatively few, but CBD drug interactions raise concerns about your health. When you take blood-thinning medications, like Warfarin, you may have side effects or interactions with the hemp oil. Hemp oil and blood thinners do not have a positive interaction. Studies into the use of blood thinners and CBD oil show that it actually increases the amount of the blood thinner in the blood.
Depressant Medications With CBD Use
If you take Warfarin or a similar blood thinning medication, then you may need to reduce your dosage while you use CBD oil for pain management or other health concerns. Discuss the risks associated with hemp oil and blood thinners with your doctor before you start using CBD oil for pain management or other symptoms.
The use of CBD oil for inflammation and pain has become an exciting options for people who suffer (see our article, What is CBD? for more information). It offers a natural alternative to pain relievers that may help reduce certain health risks. The challenge is recognizing the potential dangers from interactions with your prescription medications. By evaluating the risks, you are able to discuss the benefits of using CBD oil with a medical professional to avoid potential drug interactions.
When you take a medication that your liver breaks down into a different substance in your body, such as Prilosec or Motrin, you may have interactions with CBD oil. CBD drug interactions with different medications depend on the way your liver breaks down the medication and uses the medication in your body. In many cases, the interaction will cause your body to increase the effectiveness of the drug or increase the amount of the drug in your system.
The negative side effects of CBD oil are not limited to medications that your liver breaks down or that thin your blood. CBD drug interactions with depressants are an area of concern. You should not use CBD oil and alcohol, or any other depressant, at the same time. The CBD oil may cause extreme drowsiness or sleepiness when combined with a depressant.
Provided an anticoagulant isn’t metabolized by your CYP450 system (which also metabolizes CBD), there is a possibility that it can be used together with CBD without causing undesirable effects such as prolonged bleeding. Potentially acceptable anticoagulants include Apixaban and Rivaroxaban.
Dabigatran is another oral anticoagulant that isn’t metabolized through the CYP450 system. What’s more, this blood thinner is one of the few identified with no drug-drug or drug-food interactions. It can be considered a viable substitute for Warfarin. Nevertheless, you should always consult a health practitioner before using any anticoagulant alongside CBD, even a Warfarin substitute.
Essentially, CBD can have an additive or synergistic effect with blood thinners. “Additive” would mean that the resultant effect of using the substances together is the combined power of their individual effects. On the other hand, “synergistic” would mean that using the substances together would have a greater effect than the sum of their individual effects. That means that CBD could effectively increase the potency of your prescribed blood thinner, which could be dangerous.
What Is the Best Way to Take CBD When Using Blood Thinners?
These side effects are serious and require immediate medical attention.
9 mg/ml compared to
Blood thinners are medications, taken orally or intravenously, to prevent blood clots from forming. Clots can block the flow of blood to your heart, brain, and lungs. While blood clotting is a vital process in your body, too much clotting can trigger potentially dangerous complications.
Full-spectrum CBD products such as CBD oil contain a range of cannabinoids and terpenes but have a THC concentration of 0.3% or less. As such, these products contain traces of CBN and THC alongside CBD. In-vitro tests conducted to establish the effect of a cannabis extract on thrombin (enzyme in the blood that causes clotting) activity gave an IC50 value of
Thyroid medication is used to treat thyroid disorders, most commonly hypothyroidism (an underactive thyroid) via thyroid hormone replacement, and hyperthyroidism (an overactive thyroid) via anti-thyroid medication. Different medications achieve these objectives through different pathways in the body. Side effects of thyroid hormone replacement therapies include chest pain, anxiety, headaches, and vomiting. While rare, anti-thyroid medication side effects can include rash, itching, fever, aches, and headaches.
Currently, sparse research suggests that CBD can illicit problematic interactions with certain other prescription drugs. The findings are far from conclusive — further research is still needed on CBD’s interaction with different medications. Many doctors and researchers urge individuals using CBD medically or recreationally to be cautious about mixing it with other prescriptions and to consult healthcare providers about possible interactions.
Should I take CBD with thyroid medication?
Acetaminophen and CBD both are metabolized by CYP450, which lowers the effectiveness of both chemicals as they’re processed in the body. One controversial 2019 study, conducted by the University of Arkansas on mice and published in the journal Molecules, claimed that high doses of CBD contributed to liver toxicity, which could compound acetaminophen’s liver damage potential. However, the study’s authors have been accused of cherry-picking research and designing experiments to showcase potential CBD toxicity. The one study they cited with human test subjects did not show liver toxicity from CBD.
Patients using Plavix or clopidogrel should consult their physicians as to whether they should use CBD.
Further, a 1993 study conducted by pharmacology researchers at the University of California, San Francisco, and published in the journal Biochemical Pharmacology, discovered that CBD, much like grapefruit, disrupts the normal function of cytochrome P450 enzymes in mice. The study postulated that while the blockage could allow patients to take lower doses of their prescriptions, it could also cause a toxic buildup of chemicals in the body. Since this study’s publication, several scientific and medical journals have published evidence of the grapefruit-like effects of CBD in humans.