CBD’s exact mechanism of action is unclear. Unlike THC, CBD has a relatively low affinity for cannabinoid receptors in the brain. These are the molecules to which THC binds to elicit its psychoactive effects.
Among the few human trials evaluating CBD’s anxiolytic effects was one published in the Brazilian Journal of Psychiatry in 2019. For this study, 57 men were given either CBD oil or a placebo before a public-speaking event. Anxiety was evaluated using physiological measures (such as blood pressure, heart rate, etc.) and a relatively reliable test for mood states known as the Visual Analog Mood Scale (VAMS).
Clinical research has shown that CBD oil can trigger side effects. Severity and type can vary from one person to the next.
According to a 2012 study in the Journal of Experimental Medicine, rats injected with inflammatory chemicals in their hind feet experienced less inflammation and neuropathic pain when treated with an oral dose and spinal injection of CBD.
If you are thinking about using CBD oil to treat a health condition, be sure to speak with your healthcare provider to ensure that it is the right option for you.
When taken by mouth: Cannabidiol is POSSIBLY SAFE when taken by mouth or sprayed under the tongue appropriately. Cannabidiol in doses of up to 300 mg daily have been taken by mouth safely for up to 6 months. Higher doses of 1200-1500 mg daily have been taken by mouth safely for up to 4 weeks. A prescription cannabidiol product (Epidiolex) is approved to be taken by mouth in doses of up to 25 mg/kg daily. Cannabidiol sprays that are applied under the tongue have been used in doses of 2.5 mg for up to 2 weeks.
Some medications changed by the liver include nonsteroidal anti-inflammatory drugs (NSAIDs) such as diclofenac (Cataflam, Voltaren), ibuprofen (Motrin), meloxicam (Mobic), piroxicam (Feldene), and celecoxib (Celebrex); amitriptyline (Elavil); warfarin (Coumadin); glipizide (Glucotrol); losartan (Cozaar); and others. Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates) Some medications are changed and broken down by the liver. Cannabidiol might decrease how quickly the liver breaks down some medications. In theory, using cannabidiol along with some medications that are broken down by the liver might increase the effects and side effects of some medications. Before using cannabidiol, talk to your healthcare provider if you take any medications that are changed by the liver.
Likely effective for.
Cannabidiol is most commonly used for seizure disorder (epilepsy). It is also used for anxiety, pain, a muscle disorder called dystonia, Parkinson disease, Crohn disease, and many other conditions, but there is no good scientific evidence to support these uses.
Cannabidiol has effects on the brain. The exact cause for these effects is not clear. However, cannabidiol seems to prevent the breakdown of a chemical in the brain that affects pain, mood, and mental function. Preventing the breakdown of this chemical and increasing its levels in the blood seems to reduce psychotic symptoms associated with conditions such as schizophrenia. Cannabidiol might also block some of the psychoactive effects of delta-9-tetrahydrocannabinol (THC). Also, cannabidiol seems to reduce pain and anxiety.
Some medications changed by the liver include amitriptyline (Elavil), codeine, desipramine (Norpramin), flecainide (Tambocor), haloperidol (Haldol), imipramine (Tofranil), metoprolol (Lopressor, Toprol XL), ondansetron (Zofran), paroxetine (Paxil), risperidone (Risperdal), tramadol (Ultram), venlafaxine (Effexor), and others. Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) Some medications are changed and broken down by the liver. Cannabidiol might decrease how quickly the liver breaks down some medications. In theory, using cannabidiol along with some medications that are broken down by the liver might increase the effects and side effects of some medications. Before using cannabidiol, talk to your healthcare provider if you take any medications that are changed by the liver.
It's worth noting that there can be some side effects from taking CBD pills, but most of them are very mild. For example, they may make you drowsy or lethargic. Junella Chin, DO, an osteopathic physician and a medical cannabis expert for cannabisMD, told Health that roughly 5% of people feel something after taking CBD. "Usually they're the same people who have side effects from Advil or Tylenol," she said. However, these side effects can usually be avoided through proper dosing.
One drawback to ingestible pills is that they don't always work as fast as a CBD tincture. This is thanks to the digestive system, which allows for a slower absorption of CBD into the bloodstream as it breaks down the CBD pill over time.
One word of caution: The Food and Drug Administration (FDA) has not reviewed CBD capsules or any other mainstream high-quality products. Because of this, it is even more imperative that consumers make informed, safe decisions about which CBD pills they use. Additionally, you may want to initiate a discussion with your physician before introducing CBD.
Best for Beginners: Plus CBD Softgels
If you’ve never tried CBD pills before, the Plus CBD Softgels are a quality product to start with. These capsules feature full-spectrum hemp, without a lot of additives or extra ingredients (there are only four total items in the ingredient list). These 5-star softgels are vegan friendly and contain 15 milligrams of CBD in each, which is perfect for newcomers who wish to start out with a lower dose capsule. The brand offers 60-count bottles for a month-long supply (or longer) as well as a 10-count bottle for those looking to sample the product at a fair price.
Some people prefer to completely avoid THC when it comes to their hemp products, especially if they are concerned with taking a drug test. So if you’re shopping for an isolate CBD pill, the Medterra gel capsules are worth a try. These capsules, which have a 4.5-star rating, are made with 99.6% pure CBD derived from high-quality Kentucky hemp plants, and the products are completely devoid of THC. A bit of MCT oil is added to provide a smooth liquid suspension, and customers have the option to choose between two strengths: 25 or 50 milligrams per capsule.
Be sure to consult your physician, along with product packaging and lab reports, to learn more about potency of a product to ensure appropriate dosing.
Each capsule from Joy Organics is thoroughly lab tested, Made in the USA, and completely THC-free. If you like the combination of CBD and melatonin, you can subscribe for monthly delivery and save on each bottle.