To avoid interactions, tell your doctor and pharmacist about all prescription, over-the-counter, herbal, or recreational drugs you are taking.
Outside of these two disorders, CBD’s effectiveness in treating seizures is uncertain. Even with Epidiolex, it is uncertain whether the anti-seizure effects can be attributed to CBD or some other factor.
There is some evidence that CBD interacts with seizure medications such as Onfi (clobazam) and boosts their concentration in the blood. Further research is needed.
Dosage and Preparation
There is currently no known “correct” dose of CBD oil. Depending on individual needs and what is being treated, the daily dose may range between 5 and 25 mg.
CBD’s exact mechanism of action is unclear. Unlike THC, CBD has a relatively low affinity for cannabinoid receptors in the brain. These are the molecules to which THC binds to elicit its psychoactive effects.
Human studies evaluating the use of CBD in treating chronic pain are lacking. Those that do exist almost invariably include THC, making it difficult to isolate CBD’s distinct effects.
Part of this response could be explained by the way that CBD acts in the brain. In low doses, CBD may act as an agonist to several receptor sites, meaning it acts similarly to surrounding molecules that normally bind to the receptor, enhancing the signalling of those receptor sites. At higher doses, however, too much activity at the receptor site can lead to an opposite effect, negating the beneficial effects of CBD.
The next challenge is finding products that are accurately labeled. According to research published in November 2017 in the Journal of the American Medical Association, many CBD products do not contain the amount of CBD their labels claim. The research, conducted at the University of Pennsylvania Perelman School of Medicine, involved testing 84 CBD products to see if they contained the amount of CBD listed. The researchers found 70 percent of CBD products are mislabeled, and “26 percent contained less CBD than labeled, which could negate any potential clinical response.”
It seems like everywhere you look, cannabidiol, better known as CBD, is being touted as a cure for, well, anything that might ail you. At last check, you can find CBD in hundreds of products meant to relieve all manner of pain and anxiety, and in lifestyle-enhancing products like sports-recovery balms, personal lubricants, sleeping aids, and energy boosters that might keep you up all night (yep, take your pick!).
But first, what is CBD? Cannabidiol is a nonpsychoactive compound found in both cannabis and hemp plants, which are different varieties of the same plant species. Cannabis plants are often grown in order to cultivate tetrahydrocannabinol (THC), which is the component in marijuana that is responsible for the “high” feeling in people who smoke or ingest it. Many hemp plants, on the other hand, have had the THC largely bred out of them, according to a report published in November 2016 in Critical Reviews in Plant Sciences. These plants are grown for a variety of products, including textiles, insulation, food, paper, supplements, and skin-care items.
Is CBD Right for You, and What Are the Possible Side Effects?
Here’s a look at what a handful of scientific studies have found in recent years concerning CBD's medical usefulness, including some diseases and ailments for which the FDA has approved CBD products.
While headlines may lead you to believe that CBD — sold in oils, edibles, tinctures, creams, capsules, and more — is a cure-all, there are really just a handful of conditions that scientific studies suggest it can treat, according to a report published in 2018 by the World Health Organization. It's important to know that CBD is treated by the Food and Drug Administration (FDA) the same way as dietary supplements — that is, like supplements, CBD products can go to market without scientific evidence that they actually work. It's a “buyer beware” situation.
If you’re suffering from any of the ailments or diseases on this list and are curious to see if CBD could help, you should also know about the side effects that some people experience when using CBD products. The most common are dizziness, dry mouth, mood changes, gastrointestinal issues — including nausea — and fatigue. And since research has shown that CBD can interact with a variety of medications, including warfarin (a blood thinner) and clobazam (used to treat epilepsy), it’s essential to discuss your use of CBD-containing products with your physician or other healthcare provider.
Like any other product, from aspirin to zinc oxide, CBD is not for everyone. And even though it’s “natural,” it’s not necessarily safe, especially for people who are taking other medications. If you decide to try CBD products, make sure you know where the products are sourced from, how they’re manufactured, and how they’re meant to be used.