A laboratory study found that CBD prevented human sebocytes from creating too much sebum in addition to having an anti-inflammatory effect, preventing inflammatory cytokines from activating. Because excessive sebum and inflammation are characteristic of acne, topical CBD could be an effective treatment for acne and may prevent or reduce future breakouts. 12,13
Other trials of 300 mg of CBD in people with anxiety or depression showed that CBD appeared to preserve sleep architecture, meaning it was unlikely to have any negative effects on sleep quality. 10
31% of people taking CBD for other conditions such as anxiety or non-cancer-related pain reported improved sleep with CBD. 8
In a large case series of 72 people, 48 patients (66.7%) reported an improvement in sleep scores within the first month, but these fluctuated over time. 9
Many other studies, both on animals and humans, have overwhelmingly concluded that CBD has immunosuppressive and anti-inflammatory properties which may make it a good choice for some autoimmune conditions or inflammation-related complaints. 16
CBD has also been investigated for use in other forms of treatment-resistant epilepsy, usually in addition to conventional epilepsy medications. Results varied, but several trials showed CBD significantly reduced seizure frequency by almost 44% in most people. 3
Other research (both animal and human) has shown that CBD has anti-inflammatory effects, and it may relieve pain by this mechanism.
CBD can interact with other medications used to treat heart conditions or immunosuppressants so you should always talk with your doctor before taking CBD.
Pretreatment with 300mg CBD significantly relieved anxiety in 57 healthy males who undertook a simulated public speaking test. However, dosages of 150mg CBD and 600mg CBD did not make any difference to the men’s anxiety levels. 7
If you’re suffering from any of the ailments or diseases on this list and are curious to see if CBD could help, you should also know about the side effects that some people experience when using CBD products. The most common are dizziness, dry mouth, mood changes, gastrointestinal issues — including nausea — and fatigue. And since research has shown that CBD can interact with a variety of medications, including warfarin (a blood thinner) and clobazam (used to treat epilepsy), it’s essential to discuss your use of CBD-containing products with your physician or other healthcare provider.
Here’s a look at what a handful of scientific studies have found in recent years concerning CBD's medical usefulness, including some diseases and ailments for which the FDA has approved CBD products.
The next challenge is finding products that are accurately labeled. According to research published in November 2017 in the Journal of the American Medical Association, many CBD products do not contain the amount of CBD their labels claim. The research, conducted at the University of Pennsylvania Perelman School of Medicine, involved testing 84 CBD products to see if they contained the amount of CBD listed. The researchers found 70 percent of CBD products are mislabeled, and “26 percent contained less CBD than labeled, which could negate any potential clinical response.”
Is CBD Right for You, and What Are the Possible Side Effects?
While headlines may lead you to believe that CBD — sold in oils, edibles, tinctures, creams, capsules, and more — is a cure-all, there are really just a handful of conditions that scientific studies suggest it can treat, according to a report published in 2018 by the World Health Organization. It's important to know that CBD is treated by the Food and Drug Administration (FDA) the same way as dietary supplements — that is, like supplements, CBD products can go to market without scientific evidence that they actually work. It's a “buyer beware” situation.
It seems like everywhere you look, cannabidiol, better known as CBD, is being touted as a cure for, well, anything that might ail you. At last check, you can find CBD in hundreds of products meant to relieve all manner of pain and anxiety, and in lifestyle-enhancing products like sports-recovery balms, personal lubricants, sleeping aids, and energy boosters that might keep you up all night (yep, take your pick!).
But first, what is CBD? Cannabidiol is a nonpsychoactive compound found in both cannabis and hemp plants, which are different varieties of the same plant species. Cannabis plants are often grown in order to cultivate tetrahydrocannabinol (THC), which is the component in marijuana that is responsible for the “high” feeling in people who smoke or ingest it. Many hemp plants, on the other hand, have had the THC largely bred out of them, according to a report published in November 2016 in Critical Reviews in Plant Sciences. These plants are grown for a variety of products, including textiles, insulation, food, paper, supplements, and skin-care items.
Like any other product, from aspirin to zinc oxide, CBD is not for everyone. And even though it’s “natural,” it’s not necessarily safe, especially for people who are taking other medications. If you decide to try CBD products, make sure you know where the products are sourced from, how they’re manufactured, and how they’re meant to be used.
CBD has been touted for a wide variety of health issues, but the strongest scientific evidence is for its effectiveness in treating some of the cruelest childhood epilepsy syndromes, such as Dravet syndrome and Lennox-Gastaut syndrome (LGS), which typically don’t respond to antiseizure medications. In numerous studies, CBD was able to reduce the number of seizures, and, in some cases, it was able to stop them altogether. Videos of the effects of CBD on these children and their seizures are readily available on the Internet for viewing, and they are quite striking. Recently the FDA approved the first ever cannabis-derived medicine for these conditions, Epidiolex, which contains CBD.
Cannabidiol (CBD) has been recently covered in the media, and you may have even seen it as an add-in booster to your post-workout smoothie or morning coffee. What exactly is CBD? Why is it suddenly so popular?
The evidence for cannabidiol health benefits
Side effects of CBD include nausea, fatigue and irritability. CBD can increase the level in your blood of the blood thinner coumadin, and it can raise levels of certain other medications in your blood by the exact same mechanism that grapefruit juice does. A significant safety concern with CBD is that it is primarily marketed and sold as a supplement, not a medication. Currently, the FDA does not regulate the safety and purity of dietary supplements. So, you cannot know for sure that the product you buy has active ingredients at the dose listed on the label. In addition, the product may contain other (unknown) elements. We also don’t know the most effective therapeutic dose of CBD for any particular medical condition.
CBD may offer an option for treating different types of chronic pain. A study from the European Journal of Pain showed, using an animal model, CBD applied on the skin could help lower pain and inflammation due to arthritis. Another study demonstrated the mechanism by which CBD inhibits inflammatory and neuropathic pain, two of the most difficult types of chronic pain to treat. More study in humans is needed in this area to substantiate the claims of CBD proponents about pain control.
CBD stands for cannabidiol. It is the second most prevalent of the active ingredients of cannabis (marijuana). While CBD is an essential component of medical marijuana, it is derived directly from the hemp plant, which is a cousin of the marijuana plant. While CBD is a component of marijuana (one of hundreds), by itself it does not cause a "high." According to a report from the World Health Organization, "In humans, CBD exhibits no effects indicative of any abuse or dependence potential…. To date, there is no evidence of public health related problems associated with the use of pure CBD."